Systems, methods, and devices for promoting eyelash hair growth includes an energy transducer, positionable proximate the eyelid, configured to provide light energy to a user's eyelids at an output wavelength suitable for stimulating eyelash hair growth, and a scleral shield, positionable inside of the eyelid, to protect the eye from the light energy. The device may be powered by an internal power source, such as a rechargeable battery or disposable batteries, or by an external power source, such as a plug used in connection with an AC outlet. In use, the eyelid is positioned between the energy transducer and the scleral shield, and the light energy from the energy transducer is applied to the eyelash region of the eyelid to promote eyelash hair growth.

Methods and apparatus to improve or restore vision by causing a rebooting of the visual system of an eye with modification of visual search, sampling and stimulation away from the preferred retinal locus of fixation of an eye to enhance neural integration and perception of visual information from within the field of view are described herein. Some embodiments cause transient, reversible or repeatable redirection of environmental light away from the preferred retinal locus of fixation of an eye to multiple retinal locations that are not the preferred retinal locus of fixation. Some embodiments reduce exposure of environmental light at the preferred retinal locus of fixation of an eye for a determinable interval at a determinable rate. Some embodiments cause a defocusing of environmental light at the preferred retinal locus of fixation in an eye with a visual impairment or loss.

Embodiments of a modulable absorption light adjustable lens (MALAL) comprise a light adjustable lens that is capable of changing its optical properties upon an adjusting irradiation, including a photo-modifiable material; and a modulable absorption front protection layer, including a modulable absorption compound whose absorption properties can be modulated with a modulating stimulus. Other embodiments include a method of adjusting an optical property of a modulable absorption light adjustable lens, the method comprising: reducing an absorption of a modulable absorption compound of a modulable absorption front protection layer of the MALAL by a modulating stimulus, the MALAL having been previously implanted into an eye; and changing an optical property of a light adjustable lens of the MALAL by applying an adjusting irradiation.

A system includes a radiation source and a controller. The controller is configured to designate, for irradiation, multiple target regions on an eye of a patient, and to perform an iterative process that includes, during each iteration of the process, acquiring an image of the eye, based on the image, calculating a location of a different respective one of the target regions, processing the image so as to identify any obstruction at the location, and provided no obstruction at the location is identified, causing the radiation source to irradiate the location. Other embodiments are also described.

An ophthalmic treatment system and method for performing therapy on target tissue in a patient's eye. A delivery system delivers treatment light to the patient's eye and a camera captures a live image of the patient's eye. Control electronics control the delivery system, register a pre-treatment image of the patient's eye to the camera's live image (where the pre-treatment image includes a treatment template that identifies target tissue within the patient's eye), and verify whether or not the delivery system is aligned to the target tissue defined by the treatment template. The control electronics control the delivery system to project the treatment light onto the patient's eye in response to both an activation of a trigger device and the verification that the delivery system is aligned to the target tissue, as well as adjust delivery system alignment to track eye movement.

Devices and methods for novel retinal irradiance distribution modification (IDM) to improve, stabilize or restore vision are described herein. Also encompassed herein are devices and methods to reduce vision loss from diseases, injuries and disorders that involve damaged and/or dysfunctional and/or sensorily deprived retinal cells. Conditions that may be treated using devices and methods described herein include macular degeneration, diabetic retinopathy and glaucoma. Therapy provided by retinal IDM devices and methods described herein may also be used in combination with other therapies including, but not limited to, pharmacological, retinal laser, gene and stem cell therapies.

The disclosed subject matter provides systems and methods for modulating cytokine activity in a tissue. The system and methods can be used in a variety of tissues including the cornea. The methods of the disclosed subject matter includes a method of modulating cytokine activity within a cornea without treating keratoconus or altering curvature of the cornea, the method comprising: controlling a light source to apply light energy pulses to corneal tissue; wherein the light energy pulses: (a) are below an optical breakdown threshold for the cornea; (b) ionize water molecules within the treated corneal layer to generate reactive oxygen species; and modulate cytokine activity.

A source of light energy such as a source of violet light energy is coupled to a structure configured to contact the eye. The light source and structure are arranged to provide therapeutic amounts of violet light energy to the eye in order to inhibit the progression of refractive error such as myopia. The light source can be configured in many ways and may comprise a radioisotope and a phosphorescent material. The structure configured to contact the eye may comprise a contact lens or an implant.

A process for safely providing retinal phototherapy includes generating first and second light beams of a different wavelength. The first and second light beams are applied to a retinal pigment epithelium (RPE) and choroid of an eye. The amount of light reflected from the eye from the first light beam and the second light beam is measured, such as using a reflectometer. A level or concentration of the melanin within the eye is calculated using the measured amount of light reflected from the eye from the first and second light beams. When the content or density of melanin in the RPE exceeds a predetermined amount, one or more treatment parameters of the retinal phototherapy is adjusted.

The present disclosure provides methods for preventing or treating ocular diseases such as diabetic retinopathy and diabetic macular edema, wherein the methods include administering non-invasive photobiomodulation light therapy comprising a light having a wavelength in a red wavelength range. Biomarkers and diagnostic assays for selecting a treatment are also provided.