Embodiments of the present disclosure relate to methods and apparatus relating to corneal collagen crosslinking (CXL). In some embodiments, disclosed methods and apparatus provide boosted oxygen diffusion into corneal stroma and make possible efficacious accelerated CXL using a non-contact apparatus that reduces use of disposable supplies. In some embodiments, increased atmospheric oxygen concentration around a corneal outer surface occurs, which increases oxygen diffusion into stroma. Accordingly, in some embodiments, increased CXL efficacy occurs as well as reduced overall procedure time.

An antimicrobial treatment system comprises a wearable photoactivation device. The wearable photoactivation device includes a body configured to be positioned on a head of a subject over one or more eyes of the subject. The body includes one or more windows or openings that allow the one or more eyes to see through the body. The body includes one or more photoactivating light sources coupled to the body and configured to direct photoactivating light to the one or more eyes according to illumination parameters. The illumination parameters determine a dose of the photoactivating light that activates, according to photochemical kinetic reactions, a photosensitizer applied to the one or more eyes and generates reactive oxygen species that provide an antimicrobial effect in the one or more eyes, without substantially inducing cross-linking activity that produces biomechanical changes in the one or more eyes.

A cross-linking device and system are disclosed. In various embodiments, a cross-linking device includes a main body including a sidewall, a corneal gripping portion positioned in the interior cavity and defining an anterior chamber and an ocular chamber and defining an aperture that is configured to allow passage of a portion of a cornea to extend into the anterior chamber. In various embodiments, the device includes a multi-purpose fluid port positioned on the sidewall and defining two or more fluid pathways that connect a pair of exterior ports to an anterior chamber port, and an ocular chamber port respectively to allow for fluids to pass into and out of the interior of the device. In various embodiments the device is constructed from elastomer and, in response to a vacuum, the corneal gripping portion is configured to conform to the eye and seal the anterior chamber.

A magnetic positioning system and related method for automated or assisted eye-docking in ophthalmic surgery. The system includes a magnetic field sensing system on a laser head and a magnet on a patient interface to be mounted on the patient's eye. The magnetic field sensing system includes four magnetic field sensors located on a horizontal plane for detecting the magnetic field of the magnet, where one pair of sensors are located along the X direction at equal distances from the optical axis of the laser head and another pair are located along the Y direction at equal distances from the optical axis. Based on relative magnitudes of the magnetic field detected by each pair of sensors, the magnetic field sensing system determines whether the patient interface is centered on the optical axis. The system controls the laser head to move toward the patient interface until the latter is centered on the optical axis.

The present disclosure provides an intralocular-lens (IOL) or ophthalmic device including an optic and at least one haptic, at least a portion of which is formed from a photoresponsive shape memory polymer network, such as a polydomain azo liquid crystalline polymer network (PD-LCN). The present disclosure further provides systems and methods for adjusting the position of such an IOL or other ophthalmic device using polarized laser radiation.

At least one pulsed light beam is applied to eye tissue to raise the temperature of the eye tissue to photostimulate the tissue. The at least one light beam has parameters of wavelength, duty cycle, power and pulse train duration selected to achieve a therapeutic or prophylactic effect while not permanently damaging the eye tissue. The eye tissue photostimulation improves ocular health and function and slows or prevents disorders associated with a normally aging eye.

Apparatus for medical treatment includes a laser source, which is configured to output a beam of laser radiation. An optical device is configured to direct the laser radiation to impinge on a limbal area of an eye with optical properties chosen so as to apply a desired treatment to a tissue structure associated with a cornea of the eye within the limbal area.

A device for applying a bubble of a substance to a tissue surface, the device comprising a cannula, a distal tip at the distal end portion of the cannula, the distal tip having a bubble support surface and an exit port extending through the bubble support surface, an expansion fluid passageway extending through the cannula to the exit port, a source of an expansion fluid and an actuator therefor. In some arrangements, the distal tip can be configured to support a layer of the substance thereon over the distal port and the device can be configured such that the advancement of the expansion fluid from the fluid source through the exit port causes at least one bubble of the substance to form on the distal tip, wherein the at least a portion of the bubble can be transferred to the tissue surface to treat a defect on the tissue surface.

An ophthalmic treatment system and method for performing therapy on target tissue in a patient's eye. A delivery system delivers treatment light to the patient's eye and a camera captures a live image of the patient's eye. Control electronics control the delivery system, register a pre-treatment image of the patient's eye to the camera's live image (where the pre-treatment image includes a treatment template that identifies target tissue within the patient's eye), and verify whether or not the delivery system is aligned to the target tissue defined by the treatment template. The control electronics control the delivery system to project the treatment light onto the patient's eye in response to both an activation of a trigger device and the verification that the delivery system is aligned. to the target tissue, as well as adjust delivery system alignment to track eye movement.

A stimulus is configured to treat astigmatism with changes in retinal thickness, independently of, or in combination with, treatment for myopia. In some embodiments, a stimulus pattern is arranged with respect to an astigmatic axis of the eye to decrease ocular growth in relation to the astigmatic axis. In some embodiments, the apparatus is configured to direct light to regions of retina outside the macula in relation to the astigmatic axis of the eye. In some embodiments, the intensity is modulated to provide the effect. A lens, such as a contact lens or spectacle lens may be configured with a plurality of light sources, such as projection units having a light source and focusing optics that work together to project anteriorly or posteriorly defocused images onto the retina at locations eccentric to the fovea.