A device and a method for the femtosecond laser surgery of tissue, especially in the vitreous humor of the eye. The device includes an ultrashort pulse laser with pulse widths in the range of approximately 10 fs-1 ps, especially approximately 300 fs, pulse energies in the range of approximately 5 nJ-5 J, especially approximately 1-2 J and pulse repetition rates of approximately 10 kHz-10 MHz, especially 500 kHz. The laser system is coupled to a scanner system which allows the spatial variation of the focus in three dimensions (x, y and z). In addition to the therapeutic laser/scanner optical system, the device includes a navigation system.

Methods and systems are disclosed for creating an aqueous flow pathway in the trabecular meshwork, juxtacanalicular trabecular meshwork and Schlemm's canal of an eye for reducing elevated intraocular pressure. Some embodiments described apparatus and methods useful in photoablation of tissues. In some embodiments, a photoablation apparatus is used to perforate a tissue, forming an aperture into a space behind the tissue. Gases formed during a photoablation process can be used to pressurize the space behind the tissue to enhance patency of the space. In some embodiments the tissue is the trabecular meshwork of the eye and a wall of Schlemm's canal, and the space behind the tissue is a portion of the lumen of Schlemm's canal. In some embodiments, the method is useful in the treatment of glaucoma by improving outflow from the anterior chamber of the eye into Schlemm's canal, reducing intraocular pressure.

Systems and methods of real-time laser control and modulation for ophthalmic devices are described. The systems and methods can be used for precise laser delivery at sub-micron resolution in both laser treatment and scan imaging processes. In various embodiments, the systems can include a laser delivery device useful for surgical eye treatment, a laser delivery device useful for an ophthalmic scan imaging device, or both. In one embodiment, the system includes a laser surgery device integrated with a scan-based ophthalmic imaging apparatus. In such an embodiment, an eye motion signal obtained from the imaging apparatus can be used to provide fine-tuned control of the operation of the surgical laser beam in the laser surgery device.

A steerable laser probe may include a handle, an actuation structure of the handle, a housing tube, a flexible tube, an optic fiber, and a wire having a pre-formed curve. The flexible tube may be disposed within the housing tube wherein a distal end of the flexible tube projects out from a distal end of the housing tube. The optic fiber may be disposed within an inner bore of the handle, the housing tube, and the flexible tube. The wire may be disposed within the housing tube.

Systems and methods for removing an epithelial layer disposed over a stromal layer in a cornea irradiate a region of the epithelial layer with a pulsed beam of ablative radiation. The ablative radiation is scanned to vary the location of the beam within the region in accordance with a pulse sequence. The pulse sequence is arranged to enhance optical feedback based on a tissue fluorescence of the epithelial layer. The penetration of the epithelial layer is detected in response to the optical feedback. The use of scanning with the pulse sequence arranged to enhance optical feedback allows large areas of the epithelium to be ablated such penetration of the epithelial layer can be detected.

A steerable laser probe may include a handle having a handle distal end and a handle proximal end, an actuation control of the handle, a housing tube having a housing tube distal end and a housing tube proximal end, a first housing tube portion having a first stiffness, a second housing tube portion having a second stiffness, an optic fiber disposed within an inner portion of the handle and the housing tube, and a cable disposed within the housing tube and the actuation control. A rotation of the actuation control may be configured to gradually curve the housing tube and the optic fiber. A rotation of the actuation control may be configured to gradually straighten the housing tube and the optic fiber.

A programmable graphic projection light source system for ophthalmology includes a light source, a flexible screen, a reflective coating, and a light-shielding plate that is located between the light source and a pupil. The light source irradiates light away from the light-shielding plate. The flexible screen is located opposite the light-shieling plate crossing the light source. The reflective coating is located opposite the light source crossing the flexible screen. After the light is reflected by a central, spherical face portion of the reflective coating, a part of the light transferring a pattern from the flexible screen is blocked by the light-shielding plate, and another part of the light irradiates orthographically onto a periphery of the pupil. After the light is reflected by a plane portion of the reflective coating, a part of the light transferring the pattern irradiates obliquely onto the pupil.

A device for delivering ablative medical treatments to improve biomechanics comprising a laser for generating a beam of laser radiation used in ablative medical treatments to improve biomechanics, a housing, a controller within the housing, in communication with the laser and operable to control dosimetry of the beam of laser radiation in application to a target material, a lens operable to focus the beam of laser radiation onto a target material, and a power source operable to provide power to the laser and controller.

A method for testing a laser device configured to emit pulsed, focused laser radiation includes providing an artificial eye body with a pattern that simulates a pupil and/or an iris structure. An irradiation test object is arranged above the pattern. The irradiation test object is separate from the eye body and is made of a material that is modifiable by the laser radiation. The laser radiation is applied to the irradiation test object according to a predefined application profile, so that a material modification that corresponds to the application profile is generated in the irradiation test object.

According to various aspects and embodiments, a system and method for treating a target condition are provided. The treatment system may comprise a launch platform, a light source, and a controller coupled to the light source. The launch platform may include a substrate, a layer of absorption material, and a layer of microparticles comprising at least one therapeutic agent. The microparticles may be launched from the launch platform using light energy emitted from the light source and directed to a target condition for purposes of delivering a therapeutic agent to the target condition.