Systems, devices and methods are provided that provide assistance in selecting appropriate interventions for treatment of disease and injury to the eye. Systems of the inventive concept provide cloud-based processing and storage of clinical and patient-specific data, which can provide treatment recommendations and projected outcomes to a practitioner using a local device. Systems, devices, and methods can generate interactive physiomechanical models of the eye of a specified individual, which are derived measurements of mechanical properties of structures of the eye. The physiomechanical model is interactive, and can be used to emulate the effects of one or more medical interventions in the eye in order to implement an optimized treatment plan for the individual.

The present disclosure relates to a system for treating a cornea of a human eye using laser radiation. The system includes a laser system and a control system, which is configured to control the laser system for performing (a) a reshaping laser ablation for ablating a portion of a stroma of the cornea; and (b) a laser surface treatment. The laser surface treatment is a substantially optically non-corrective treatment of a reshaped surface portion. The reshaped surface portion represents a corrective or non-corrective reshaping of an anterior surface of the cornea and is formed using the reshaping laser ablation. A maximum ablation depth of the laser surface treatment is less than 5 micrometers or less than 3 micrometers.

Example eye treatments detennine an area at a surface of a cornea for delivery of a cross-linking agent. The example treatments disrupt tissue at the area at the surface of the conlea up to a depth corresponding to apical layers of superficial squamous cells of the cornea, e.g., no greater than approximately 10 m to approximately 15 lm. The example treatments apply a cross-linking agent to the area at the surface of the cornea. The cross-linking agent is transmitted through the disrupted area at a greater rate relative to non disrupted areas of the cornea. The example treatments deliver photoactivating light to the cornea. The photoactivating light activates the cross-linking agent to generate cross-linking activity in the cornea.

A composition includes particles for use in a method for the treatment of a vitreous disease or a vitreous disorder as a light sensitizing agent. Each particle has a surface selected for or adapted for providing mobility of the particle in the vitreous and for binding to collagen aggregates, such as floaters.

A method for altering an eye color of a patient with a color alteration procedure is disclosed that may include determining a laser power to deliver to stromal pigment in an iris of the eye of the patient by at least retrieving a set of laser criteria for delivery of an exposure less than 100 times a maximum permissible exposure that causes elimination of at least a portion of the stromal pigment. A laser system may be set to deliver laser light at the laser power which is less than the set of laser criteria and the laser light may be delivered with the laser system.

Systems for treatment of glaucoma comprise an excimer laser, a plurality of fiber probes, and a processor. Each fiber probe is attachable to the excimer laser to treat a subject having glaucoma by delivering shots from the laser. The processor is configured to monitor and limit a variable number of shots delivered by each fiber probe, the number of shots delivered by each fiber probe programmable within a range. Methods of treating glaucoma include programming a fiber probe to deliver a number of shots from an excimer laser. The fiber probe is inserted into an eye of a subject having glaucoma and adjusted to a position transverse to Schlemm's canal in the eye. A plurality of shots is applied from the excimer laser source while the probe is in the transverse position, thereby treating glaucoma by creating a plurality of perforations in Schlemm's canal and/or the trabecular meshwork.

The present disclosure relates to a system for treating a cornea of a human eye using laser radiation. The system includes a laser system and a control system, which is configured to control the laser system for performing (a) a reshaping laser ablation for ablating a portion of a stroma of the cornea; and (b) a laser surface treatment. The laser surface treatment is a substantially optically non-corrective treatment of a reshaped surface portion. The reshaped surface portion represents a corrective or non-corrective reshaping of an anterior surface of the cornea and is formed using the reshaping laser ablation.

A system for a treatment with laser of pigmented ocular tissues. the system comprising a first subsystem (1) for imaging an pigmented ocular tissue of a person. a second subsystem (2) for planning a laser treatment of the pigmented ocular tissue, and a third subsystem (3) for performing the laser treatment, wherein: the first subsystem (1) comprises image analysis means (15), a camera, an optical coherence tomography apparatus (12) and at least one first head positioner (13, 14); the second subsystem (2) comprises a computer (21); the third subsystem (3) comprises an eye tracker, three or more lasers (111) of respective different wavelengths, an optical assembly (91), control means (115) and a second head positioner (92).

Microsurgical instruments having combined illumination, laser ablation, and viscoelastic injection functions. A surgical instrument includes a probe having a main lumen and a port at a distal end thereof. The probe may further include one or more optical fibers within the main lumen, the optical fibers configured to project laser light and illumination light. Laser light may be emitted from the distal end of the probe for disrupting an ocular tissue, while illumination light may be simultaneously emitted, axially or laterally, to provide enhanced visualization of the intraocular space during tissue disruptance. Upon disrupting the tissue, a viscoelastic fluid may be injected from the port to maintain an integrity of the intraocular space.

Generation of treatment recommendations for topographic-based excimer laser surgical procedures is described that includes generating accurate cylinder compensation and spherical compensation values that are adjusted to compensate for unique characteristics of advanced topographic-based excimer laser surgical systems. Generating treatment recommendations generally includes determining a topographic vector from a topographic corneal map of the eye, determining a posterior astigmatism vector and an anterior astigmatism vector for the eye, and generating an interior astigmatism vector using the topographic vector, the posterior astigmatism vector, the anterior astigmatism vector, and a manifest astigmatism vector. In various embodiments, the cylinder compensation is generated using the interior astigmatism vector and the posterior astigmatism vector, and the spherical compensation is generated using an initial spherical compensation modified by a topographic addback modifier and a cylinder addback modifier.