A stool resuspension solution comprising a hemoglobin stabilization reagent is provided. In some embodiments, the hemoglobin stabilization reagent may be an osmolyte, a polyvalent cation, a sugar or polysaccharide and, optionally, a polyvalent cation, a protoporphyrin, or an HRP stabilization component and, optionally, a polyvalent cation. A method of stabilizing hemoglobin in a stool sample in the solution is also provided, as well as a sample collection device containing the solution.

In the detection of the presence of a biomarker or the like in a sample of a flowable substance, e.g. a powder or a liquid, usually a body fluid, such as blood, urine, or saliva, for example, a disposable sample receiver (3) is used, which has a receiving chamber (301) that is dimensioned to receive a predetermined volume and is surrounded by a depression (303) receiving any excess volume for which there is no room in the receiving chamber (301). The receiving chamber (301) has a bottom outlet (302) closed by a removable strip (33), e.g. a plastic strip or foil. Upon pulling away the strip (33) from the bottom outlet, the sample in the receiving chamber is emptied into a flow path (32) leading to at least one detection compartment (321) permitting direct visual inspection. Preferably, disposable sample receiver (3) is used in a detector assembly (1) including an electronic camera (23), a CPU (26) and a display (22). Hereby, the volume of the sample to be analyzed will always be the same, and by controlling the exact point of time when the sample is passed on into the flow path (32), a high degree of repeatability and accuracy is achieved, and thereby also a fail-safe system.

Analyzers and methods for making and using analyzers are described such as a method in which multiple absorption readings of a liquid assay are obtained by a photodetector using multiple light sources having at least three separate and independent wavelength ranges and with each of the absorption readings taken at a separate instant of time. Using at least one processor and calibration information of the liquid assay, an amount of at least two analytes within the liquid assay using the multiple absorption readings is determined.

Diagnostic devices; systems, methods and computer-readable media store instructions related to determining hemoglobin information using those devices. The methods may include processing a captured image of the reservoir and/or device and the device information to determine color information for the solution and the scale, the color information including one or more color attributes; adjusting the color information for the solution based on the color information for the scale; and determining hemoglobin information (e.g., hemoglobin level, disease state and/or calculated hematocrit) based on the adjusted color information and a stored profile information associated with the device information.

Provided is a test device for testing an analyte in a collected sample comprising: an enclosure having at least one sample receiving port for receiving the sample; a test strip located within the enclosure, the test strip containing at least one reagent for detecting the analyte and for providing an indication showing a test result for the sample, the enclosure including a detection arrangement for allowing detection of the indication of the test strip; a sample receiving matrix positioned behind the at least one sample receiving port and having a defined saturation capacity, the sample receiving matrix being impregnated with reagents for pre-treatment of the sample and being in liquid conductive communication with the test strip. Also provided is a method for use of said test device comprising: delivering one or more samples to the at least one sample receiving port to saturate the sample receiving matrix such that a quantified amount of the sample is transferred to the test strip and an indication of the test result is effected.

Aspects of the present invention are directed to devices, systems and methods that enable the quick and reliable detection of hemolysis in a sample such that a sample which exhibits an unacceptable level of hemolysis can be flagged or disregarded in an associated diagnostic test.

A hemoglobin detecting method is executed by a mobile device having a hemoglobin detecting function. The mobile device includes a processor unit, a first light source that generates a first light beam, and a light detecting module that receives a second light beam that is generated when the first light beam travels through an analyte solution and is reflected. The light detecting module generates first to fourth intensity signals according to the second light beam, and the processor unit determines whether the absorption spectrum of the analyte solution matches a target spectrum. If the absorption spectrum of the analyte solution matches the target spectrum, the processor unit generates positive result information; otherwise, the processor unit generates negative result information. The mobile device provides a fast and accurate way to detect blood in a stool solution, which does not require collecting samples of stool or applying any chemical.

A biochip compatible with very small blood sample volumes is used for delecting for detecting hemoglobin disorders and monitoring disorders associated with aberrant blood cell deformability and adhesion, including disease severity, upcoming pain crisis, treatment response, and treatment effectiveness in a clinically meaningful way.

The present invention related to a reaction vessel and an assay device. A reaction vessel for analysis a sample containing an analyte to be determined, which includes a casing, a first reagent and at least one independent individual element. The casing includes an opening and a detection zone. The opening may be formed on the edge of the casing and used to introduce the sample. The detection zone is disposed at a corner of the casing and used to detect the analyte. The reagent is interacted with the sample. The independent individual element is individually separating from the casing and providing a space and a flow channel for mixing the sample and the first reagent. The sample and the reagent are mixed in the independent individual element so as to determine the analyte in the detection zone, and thereby increasing accuracy of analyte detection.

Non-limiting embodiments of a modified devices that comprise at least one dye for determining whether results obtained from the conductance of at least one diagnostic assay are biased, as well as kits and methods of use related thereto.