Devices and methods are provided for use in the treatment of bladder cancer by locally administering oxaliplatin into the bladder of a patient to achieve a sustained concentration of oxaliplatin in urine in the bladder sufficient to produce a therapeutic concentration of oxaliplatin in bladder tissue. The oxaliplatin may be delivered into the bladder from an intravesical drug delivery device inserted into the bladder, wherein the device continuously releases the oxaliplatin into the urine in the bladder over an extended period of hours or days.

Drug delivery devices having a drug-permeable component and methods of making and using the same are provided. Drug delivery devices include a housing having a first and second wall structures that are adjacent one another and together form a tube defining a drug reservoir lumen. The second wall structure, or both the first wall structure and the second wall structure, are permeable to water, and the first wall structure is impermeable to the drug while the second wall structure is permeable to the drug, such that the drug is releasable in vivo by diffusion through the second wall structure.

The invention relates to a dissolution chamber (10) for use with a catheter for dissolving and preparing an aqueous solution of a water-soluble photosensitizing agent for installation into the bladder, e.g. for use in photodynamic diagnosis (PDD) or photodynamic therapy (PDT) of bladder cancer and to a method for preparing a liquid pharmaceutical preparation for delivery into a patient's bladder which includes the use of said dissolution chamber (10).

An intra-cavity circulation heat perfusion apparatus, comprising a casing, an electromagnetic induction heating means, and a controller. The electromagnetic induction heating means comprises a tray and an electromagnetic induction coil; the tray is used for bearing a heating tank; a master control unit of the controller controls the electromagnetic induction coil to be electrified to heat the heating tank, so as to indirectly heat a medicinal liquid in a liquid storage chamber; a data acquisition unit is used for acquiring medicinal liquid temperature values of the heating tank, a liquid outlet pipeline, and a liquid return pipeline and transferring same to the master control unit; the master control unit controls a power control unit according to the medicinal liquid temperature values to control a heating power of the electromagnetic induction coil.

A catheter comprising an elongated member having a distal end and a proximal end. The proximal end defines a drainage inlet extending from an external wall of the elongated member into the elongated member. The elongated member defines a first lumen that connects the drainage inlet with a drainage outlet defined by the distal end. The catheter also includes an inflatable retention balloon defined by the external wall of the elongated member and located between the drainage inlet and the drainage outlet. The catheter further includes a fluid inlet valve that protrudes from the elongated member and defines a second lumen that extends from the fluid inlet valve through the elongated member and to the inflatable retention balloon. The catheter additionally includes a secondary balloon that protrudes from the elongated member, the elongated member defining a third lumen that extends from the inflatable retention balloon to the secondary balloon.

A negative pressure therapy system is provided for inducing negative pressure in a portion of a urinary tract of a patient, the system including: (a) at least one ureteral catheter configured to be positioned within a ureter and/or kidney of a patient; (b) one or more sensor(s) configured to determine information about urine produced within a urinary tract of the patient; and (c) a controller configured to increase urine production of the patient by adjusting one or more operating parameters of a negative pressure source for inducing negative pressure through the at least one ureteral catheter into the urinary tract of the patient, based at least in part upon the information determined by the one or more sensor(s).

A catheterization package including a catheterization tray and contents for a catheterization procedure. The catheterization tray can include a structural configuration for maintaining a sterile field about a patient throughout the catheterization procedure, the sterile field including at least a portion of the tray. The structural configuration of the tray can provide a sterile side of the tray designated for a first person performing sterile steps of the catheterization procedure in the sterile field. The structural configuration of the tray can also provide a non-sterile side of the tray designated for either the first person or a second person performing non-sterile steps of the catheterization procedure outside the sterile field. The contents for the catheterization procedure can include a perineal care kit, two or more pairs of gloves, and a drainage system including a catheter.

A device for insertion of material into a urethra comprising: a nozzle with a rounded nozzle tip, sized for at least partial insertion into the urethra; and a source of compressed material coupled to the nozzle where a pressure of the compressed material is less than 200 cm H.sub.2O; a control, for control of flow of material from the source through the nozzle; wherein a maximum extent of the device is less than 30 cm.

Disclosed herein are systems, devices, and methods for the removal of objects from the body. The device may be a urethral catheter configured to aspirate kidney stones from the urinary tract through one or more aspiration ports at the distal face or along a lateral side of the catheter. The catheter may include one or more irrigation ports at the distal face or along the lateral side of the catheter for dislodging kidney stones. The device may be steerable. The spatial arrangement of the one or more irrigation ports with respect to the one or more aspiration ports may vary. The device may include an irrigation tube and/or a shield member configured to spatially confine the kidney stones adjacent the catheter. Various temporal patterns of aspiration and irrigation are disclosed for optimizing removal of kidney stones.

A fluid extraction implantable system shaped and sized to be implanted in a patient, including: a fluid extraction chamber having a flat and thin shape connected to a draining tube and including at least one external flat surface, wherein the at least one external flat surface is configured to be attached to a tissue surface when a negative pressure is applied on the draining tube, wherein the chamber extracts fluids from the tissue by applying the negative pressure through the flat surface on the attached tissue surface.