A drug delivery device is provided. In an embodiment, the device includes a device body having an elongated drug reservoir lumen, a drug positioned in the drug reservoir lumen, and at least one end plug positioned at an end of the device body, for example inserted in an end of the drug reservoir lumen. The end plug may include an aperture therethough, and the drug delivery device may be configured to release the drug from the drug reservoir lumen through the aperture.

A system and method for drug delivery includes a pressure wave generator, and a substrate which receives a pressure wave generated by the pressure wave generator. A substance is in contact with the substrate and is propelled by the substrate into a tissue.

Ureteral catheters and assemblies are provided including: a drainage lumen including a proximal portion configured to be positioned in at least a portion of a patient's urethra and a distal portion configured to be positioned in a patient's ureter and/or kidney, the distal portion including a coiled retention portion including at least a first coil having a first diameter and a second coil having a second diameter, the first diameter being less than the second diameter; or wherein the retention portion extends radially outwardly from a portion of the distal end of the drainage lumen portion, the retention portion including a proximal end having a first diameter, a distal end having a second diameter, and a wall and/or surface extending therebetween, the retention portion having a second diameter is greater than the first diameter when deployed; or wherein the retention portion includes a plurality of drainage tubes.

The device described in this document provides a method for easily converting a urinary catheter to one that will monitor pressure changes in the anchoring balloon allowing safe deflation if a patient intentionally or unintentionally pulls on the catheter with such force that would otherwise cause traumatic injury to the urethra. The device would sound an alarm in such cases of forced removal. The device would secondarily allow monitoring of insertion date, and intraabdominal pressures among other things due to the electronic storage, display, and communication capabilities.

The present invention provides balloon catheters and methods for using the same. Unlike existing balloon catheters in the art, the present balloon catheters expand in the proximal direction to enhance fit. The balloon catheters include sliding balloon catheters, preformed balloon catheters, super-elastic balloon catheters, and may be augmented with peripheral catheters.

A device for snugging a balloon of a catheter against an inner wall of an intra-corporeal lumen or surface serviced by the catheter includes a hollow column having a top end and a bottom end, forming a throughway sized to accommodate a tube of the catheter, and a flange extending from the bottom end of the hollow column generally perpendicularly to length of the hollow column. A slit is formed in the hollow column and the flange through which the hollow column is connectable to the tube of the catheter. The catheter is tugged to contact the balloon to the inner wall of the lumen, and the device is fixed to the tube of the catheter atop the skin of a body serviced by the catheter to tension pressure of the balloon against the inner wall.

A multi-lumen catheter, for insertion into and draining a body cavity, that mitigates the risk of obstruction of the drainage ports and drainage lumen of the catheter, reduces the detrimental effects caused by the suction forces of the drainage ports on the body cavity being drained, and reduces the risk of infection of the body cavity being drained by decreasing the residual volume of fluid retained in the body cavity being drained. These advantages are achieved by the novel approach of disposing a perforated filter membrane or a membrane having a relatively large entry port(s) between membrane struts over a segmented retention element and also over the drainage port(s) of the drainage lumen of the catheter thereby creating internal interstitial drainage channels and internal interstitial drainage cavities.

An external catheter stabilizer device for stabilizing and retaining a catheter tube at a stoma includes a base portion and a central portion. The base portion is configured to be affixed at a patient so as to generally surround a stoma. The central portion has a passageway therethrough that is configured to receive a tube that passes through the stoma. The base portion is attached to the central portion via at least two spaced apart spokes. A catheter tube retaining element is disposed radially outboard of the passageway and is configured to receive and retain a portion of the catheter tube therein. When the base portion is affixed at a patient, the central portion is spaced away from the patient. The device may include features that provide both stabilization and selectable modes of operation, such as a free-flow mode and a no-flow mode.

Ureteral or bladder catheters and systems are provided, including (a) a proximal portion; and (b) a distal portion, the distal portion including a retention portion including an outer periphery or protective surface area which prevents mucosal tissue from occluding one or more protected drainage holes, ports, or perforations disposed within the outer periphery or protective surface area upon application of negative pressure through the catheter.

Disclosed herein is a method for treating a tumor having a temperature sensitive p53 (ts p53) mutation in a subject in need thereof. The method involves first administering to the subject a therapeutically effective amount of a chemotherapeutic drug, then inducing moderate hypothermia in the tumor for a duration sufficient to activate the mutant p53 to enhance the efficacy of the drug.