Ureteral catheters and assemblies are provided including: a drainage lumen including a proximal portion configured to be positioned in at least a portion of a patient's urethra and a distal portion configured to be positioned in a patient's ureter and/or kidney, the distal portion including a coiled retention portion including at least a first coil having a first diameter and a second coil having a second diameter, the first diameter being less than the second diameter; or wherein the retention portion extends radially outwardly from a portion of the distal end of the drainage lumen portion, the retention portion including a proximal end having a first diameter, a distal end having a second diameter, and a wall and/or surface extending therebetween, the retention portion having a second diameter is greater than the first diameter when deployed; or wherein the retention portion includes a plurality of drainage tubes.

A catheter and package combination including a package having opposed front and rear panels that are sealed together to define a sealed interior cavity. The package also has top and bottom edges and opposed side edges. The cavity has a first height extending in a direction between the top and bottom edges. The front and rear panels are configured to tear adjacent to one of the side edges in the direction between the top and bottom edges to form an opening in communication with the cavity wherein the opening has a second height in the direction between the top and bottom edges that is smaller than the first height of the cavity. A urinary catheter in a compact configuration is disposed within the cavity.

A drainage and/or collection system (1) for biological fluids includes at least one conduit (40) for transporting a biological fluid (F) from a catheter (10) to a collection device (50) and a gas pressure source (70) configured to feed a gas (G) into the at least one conduit (40) between the catheter (10) and the collection device (50). The gas (G) causes the biological fluid (F) arranged in the at least one conduit (40) to drain into the collection device (50). A method includes inserting a catheter (10), draining a fluid (F) into a collection device (50) via a conduit (40), and introducing gas (G) into the conduit (40) so as to force fluid (F) remaining in the conduit (40) into the collection device (50).

Provided herein are solid pharmaceutical compositions comprising an L-lactate salt of erdafitinib, processes for making such formulations, and drug delivery systems comprising such formulations, including systems for intravesical administration.

Methods, devices, and medicaments that include a drug are provided for use in the treatment of the prostate by locally administering the drug into the bladder of a patient to achieve a sustained concentration of the drug in urine in the bladder sufficient to produce a therapeutic concentration of the drug in the prostate. The drug may be delivered into the bladder from an intravesical drug delivery device inserted into the bladder, wherein the device continuously releases the drug into the urine in the bladder over an extended period of hours or days.

Irrigation devices, methods, and systems are disclosed. The system comprises a catheter with one or more lumens and an expandable portion. One or more pumps are used to supply a mixture of contrasting and dilating agents in an interior kidney volume and flush a portion of the mixture out of the interior kidney volume. The method comprises placing a catheter into the interior kidney volume through a ureter, occluding a portion of the ureter with a distal end of the catheter, forming an exit port through an exterior kidney surface, flowing the contrasting and dilating agents through the one or more lumens to supply the mixture in the interior kidney volume, and flushing a portion of the mixture out of the exit port.

An adapter is provided with a central, longitudinal, inner through hole and has a rounded off tip-part to be inserted into the external urethral orifice, a sealing collar and a cylindrical connecting part known connectable to the appropriate part of a dosing device, advantageously to the ISO 594 standard Luer Slip or Luer-Lock tip of a syringe. The adapter is connected by known method to the appropriate part of a dosing device containing the active and/or contrast agent, then the active and/or contrast agent is ingested leakage-free into the urethra or into the urethra and the bladder through the adapter, then through the external urethral orifice by using overpressure in the dosing device and inserting the tip-part into the external urethral orifice and squeezing the sealing collar in a proper way to the external urethral orifice.

A system and/or a method of evacuating cerebrospinal fluid (CSF) from a CSF reservoir is provided. The system can include a CSF reservoir, a reservoir mating piece, and a securing piece. The reservoir mating piece can have a tip end configured to be insertable into the CSF reservoir and a drainage end configured to be coupled to a drainage tube, the reservoir mating piece forming a drainage passageway for the evacuation of CSF from the CSF reservoir. The securing piece can be configured to be affixed to an individual's skin. In an unlocked position, the securing piece may be configured to slide along the reservoir mating piece, and in a locked position, the securing piece may be configured to be fixed relative to the reservoir mating piece. At least a portion of the drainage passageway is nonlinear between the tip end and the drainage end.

The present disclosure relates to a packaged urinary catheter assembly and method of using the packaged urinary catheter assembly. The catheter assembly includes a conduit having a proximal end and a distal end. The distal end includes at least one aperture for receiving fluid from a patient. The conduit is contained within a sleeve having a length, a width, and a size configured to receive the catheter. According to one embodiment, the conduit and the sleeve may be arranged in a helical coil. The outer surface of the conduit may have a lubricious and/or an antimicrobial coating.

Intravesical drug delivery devices are provided which may include an elongated body formed of a matrix system of a drug dispersed in a silicone, wherein the elongated body has a first end, an opposed second end, and an intermediate portion between the first and second ends, and wherein the silicone of the matrix system is cured to bias the elongated body in a coiled retention shape, such that the device is elastically deformable between a relatively straightened shape suited for insertion of the device through a urethra and into the urinary bladder of a patient and the coiled retention shape which is suited to retain the device within the urinary bladder.