Disclosed herein is an indwelling urinary catheter having a guidewire anchoring mechanism. The indwelling urinary catheter includes a catheter tube having a proximal opening, a distal opening, a catheter tube lumen with the catheter tube having a first wall thickness. The guidewire anchoring mechanism is configured to transition between an insertion state and an anchored state. The guidewire anchoring mechanism can include a proximal portion having a top cap, a collapsible section having a second wall thickness less than the first wall thickness, and a distal portion including a holder cap coupled to a holder. The holder can be coupled to the catheter tube, the distal portion can be in communication with the proximal portion, and a guidewire can be coupled to the proximal portion, the guidewire extending through the catheter tube lumen to the distal portion.

A negative pressure therapy system is provided for inducing negative pressure in a portion of a urinary tract, the system including: (a) at least one ureteral catheter configured to be positioned within a ureter and/or kidney; (b) one or more sensor(s) configured to determine information about at least one of blood composition, blood flow, respiration, heart rate, glucose, protein, or creatinine; and (c) a controller configured to increase urine production by adjusting one or more operating parameters of a negative pressure source for inducing negative pressure through the at least one ureteral catheter into the urinary tract, based at least in part upon the information determined by the one or more sensor(s).

Disclosed is a medical device or system comprising an elongate member having a distal end and a proximal end; an inflow lumen disposed within the elongate member, the inflow lumen having a proximal end, a distal end and a slanting exit opening at the distal end of the inflow lumen; and an outflow lumen also disposed within the elongate member, the outflow lumen having a proximal end, a distal end and a slanting receiving opening at the distal end of the outflow lumen. The disclosed medical device or system further comprises pressure sensors disposed at the distal end of the elongate member. Also disclosed is a method of employing the above disclosed device or variations thereof to remove small stones or small stone fragments from within the body's lumen or internal organ of a subject.

Devices and methods are provided for drug delivery. The device may include a housing configured for intraluminal deployment into a human or animal subject and first and second reservoirs within the housing, each reservoir having an actuation end, an opposed release end, and a plug moveable from the actuation end toward the release end. First and second drug formulations may be contained in the first and second reservoirs, respectively. The device may also include one or more actuation systems configured to drive the first and second plugs so as to drive the first and second drug formulations from the first and second reservoirs. The housing may include a porous membrane sidewall in fluid communication with the release ends of the first and second reservoirs, the porous membrane sidewall being configured to distribute the first and second drug formulations driven from the first and second reservoirs.

The invention is directed to a device in the form of a tube or catheter for draining and/or sealing a natural or artificial bladder outlet, comprising a shaft body that can be applied from extracorporeal into a bladder of the patient, as well as a balloon that surrounds the shaft body like a cuff and is placed in the bladder for the purpose of a vesical anchoring of the shaft body in the bladder, wherein the shaft body, which is produced by means of molding, is having a profile with a wavy corrugation, providing the shaft body with a radial stability and with a kink-free axial bending property.

The present invention provides balloon catheters and methods for using the same. Unlike existing balloon catheters in the art, the present balloon catheters expand in the proximal direction to enhance fit. The balloon catheters include sliding balloon catheters, preformed balloon catheters, super-elastic balloon catheters, and may be augmented with peripheral catheters.

Minimally invasive catheter relates to the field of eversible catheters. It is primarily intended for use as a urinary catheter, but is also usable in other fields. As a urinary catheter this minimally invasive catheter 1 used as an indwelling or intermittent catheter with transurethral or suprapubic approach. This catheter has specific technical solution for eversible motion where tubular membrane 2, attached between distal part 36a of the handle 36 and distal part 3a of the inner tube 3, can in one case free slide between these two parts and in another be fixed to form hermetically sealed space 14. Free sliding of membrane ensures eversible principle of motion during placement and withdrawal of the catheter 1. Fixation of membrane allows a formation of hermetically sealed space 14 with fluid to make catheter surface smoother and softer, and a balloon 33 to hold catheter 1 in place for prolonged period of time. Thus, present invention provides a urinary catheter that enables the reduced incidence of complications arising due to its application.

Provided herein are methods of treating an upper tract urothelial carcinoma in a patient by administering to the patient infigratinib or a pharmaceutically acceptable salt thereof. Also provided herein are methods of treating non-muscle invasive bladder cancer by administering to the patient infigratinib or a pharmaceutically acceptable salt thereof.

An apparatus and a corresponding method for flushing fluid through a catheter that has, or that is connected to tubing that has, a Luer lock and a Luer-lock interface, wherein the Luer lock opens when a Luer-lock connector is connected to the Luer-lock interface. In some embodiments, the system includes a monolithic structure that includes a fluid-source connector configured to removably connect to a fluid source; a Luer-lock connector configured to operatively connect to the Luer-lock interface on the catheter; and a fluid passageway between the fluid-source connector and the Luer-lock connector. Some embodiments are used for irrigating and flushing an organ (such as flushing an organ with a medication, cancer-treatment fluid, or the like, or instilling medication, cancer-treatment fluid, or the like into the organ).

Implantable drug delivery devices are provided to have a deployment shape for implantation in the body and a retention shape for retention in the body. The device may have one or more elongated drug reservoirs containing a drug, and the drug reservoir may be formed from a deformable material. In one case, a first filament is attached to the first end of the drug reservoir and second filament is attached to the second end of the drug reservoir, wherein a fastener is positioned about the first and second filaments to permit shortening and prevent lengthening of the filaments with reference to the ends of the drug reservoir, as a means for transforming the device from the implantation shape to the retention shape.