An ion-exchange apparatus includes a raw-water tank 1, a treatment section, an ion exchanger and a hydrophilic layer. The raw-water section contains a liquid to be treated with impurity ions. The treatment tank 2 contains a treatment material with exchange ions exchangeable with the impurity ions. The ion exchanger 3 enables the passage of the impurity ions from the raw-water tank 1 to the treatment tank 2 and the passage of the exchange ions from the treatment tank 2 to the raw-water tank 1. The hydrophilic layer M, with a water contact angle of 30° or less, is disposed on at least a surface of the ion exchanger adjacent to the treatment tank 2.

An inexpensive ion-exchange apparatus with an increased ion-exchange capacity has a raw-water tank (1), a treatment tank (2) and an ion exchanger (3). The raw-water tank (1) contains a to be treated liquid. The liquid contains impurity ions. The treatment tank (2) contains a treatment material that contains exchange ions exchangeable with the impurity ions. The ion exchanger (3) enables passage of the impurity ions from the raw-water tank (1) to the treatment tank (2) and the passage of the exchange ions from the treatment tank (2) to the raw-water tank (1). The treatment material in the treatment tank (2) has a higher molarity than the to be treated liquid in the raw-water tank 1.

A method that regulates supply of substituate in an extracorporeal blood treatment with an extracorporeal blood treatment apparatus comprising a dialyzer divided by a semipermeable membrane into a blood chamber and a dialyzing fluid chamber and a device for supplying substituate. An extracorporeal blood treatment apparatus that includes a device for regulating supply of substituate. Regulation of supply of substituate in the extracorporeal blood treatment takes place as a function of the rheological loading of the dialyzer. To regulate supply of substituate during extracorporeal blood treatment, rheological loading of the dialyzer is determined from transmembrane pressure on the dialyzer and flow resistance of the dialyzer and substituate rate is increased or reduced according to the loading. The selection of dialyzer parameters or blood parameters is therefore no longer necessary and the distinction between pre-dilution and post-dilution is also made obsolete.

A treatment system for performing a treatment on a patient may include a treatment fluid preparation device having a pump connected by a fluid channel to a reservoir of a source fluid, the pump conveying the source fluid from the reservoir, through a filter, and combining the source fluid with a concentrate by pumping the source fluid with the concentrate to form a treatment fluid in a batch container. The treatment fluid preparation device may have a controller that controls a heater, the pump, and a memory. The controller starts the heater to warm the treatment fluid in the batch container at a time that is responsive to the treatment time stored in the memory. The controller also detects a pressure property of the filter to determine its integrity and outputs an indication of a failed batch if the pressure property indicates the integrity of the filter is insufficient.

The invention pertains to a purification method for a biological fluid comprising at least a filtration step through a membrane obtained from a sulfone polymer [polymer (PSI)] derived from bio-based feed-stocks. In particular the PSI polymer comprises more than 50% moles recurring units (R.sub.PSI) comprising sugar moieties selected from the group consisting of those of formulae (E′-1) to (E′-3):

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The invention further relates to polymer solutions and polymer membranes comprising at least one polymer (PSI) and that are free from pore-forming agents.

A method of preparing a solution for use during a dialysis, hemodialysis, or Continuous Renal Replacement Therapy (CRRT) treatment of a patient is provided. An antibiotic or other drug is added (48, 50, 52) to a solution and the concentration or dosing of the antibiotic or other drug within the solution is adjusted (72) as required based on a determination (64) of serum level of the antibiotic in a blood sample of a patient.

The invention relates generally to methods of preparing one or more organs from a donor for transplantation to a recipient comprising passing blood from the donor through an extracorporeal membrane having a plurality of pores having an average pore size of at least 60 kDa.

Disclosed are miniaturized electronic systems, devices and methods for biomarker analysis, which can be incorporated into blood collection tubes and other containers that enable the immediate isolation, concentration, analysis and storage of disease related biomarkers upon blood draw. In some aspects, a miniaturized electronic system includes a high-surface area folded or sandwiched electrokinetic microelectrode array chip device that allows both AC dielectrophoretic (DEP) and DC electrophoretic based separation and isolation and other processes to be used for the concentration and biomarkers.

The present invention relates to a method for regulating supply of substituate in an extracorporeal blood treatment with an extracorporeal blood treatment apparatus comprising a dialyzer divided by a semipermeable membrane into a blood chamber and a dialyzing fluid chamber and a device for supplying substituate. Moreover, the present invention relates to an extracorporeal blood treatment apparatus having a device for regulating supply of substituate. Regulation of supply of substituate in the extracorporeal blood treatment takes place as a function of the rheological loading of the dialyzer. To regulate supply of substituate during extracorporeal blood treatment, rheological loading of the dialyzer is determined from transmembrane pressure on the dialyzer and flow resistance of the dialyzer and substituate rate is increased or reduced according to the loading. The selection of dialyzer parameters or blood parameters is therefore no longer necessary and the distinction between pre-dilution and post-dilution is also made obsolete.

The present technology provides micro fabricated filtration devices, methods of making such devices, and uses for microfabricated filtration devices. The devices may allow diffusion to occur between two fluids with improved transport resistance characteristics as compared to conventional filtration devices. The devices may include a compound structure that includes a porous membrane overlying a support structure. The support structure may define a cavity and a plurality of recesses formed in a way that can allow modified convective flow of a first fluid to provide improved diffusive transport between the first fluid and a second fluid through the membrane.