A chiral bimetallic cooperative catalysis system containing a chelating ligand and use thereof in asymmetric synthesis of bedaquiline are provided. Specifically, in the chiral bimetallic cooperative catalysis system, an equilibrium constant of a reaction is increased by the chelating ligand formed by an achiral secondary amine and chiral lithium aminoalcohol, thereby promoting an addition reaction between 6-bromo-3-benzyl-2-methoxyquinoline (I) and 3-dimethylamino-1-naphthyl-1-propanone (II) to move forward. By means of the bimetallic cooperative catalysis system, the yield of the target product (1R,2S)-bedaquiline is obviously increased.

Described herein is the controlled room temperature acousticmicrofluidic-based one-step template-free fabrication of porous multimetallic nanocrystals containing one or more 3d transition metals with tunable size, shape, and composition.

The present invention relates to a process of the asymmetric hydrogenation of a ketal of an unsaturated ketone or an acetal of an unsaturated aldehyde by molecular hydrogen in the presence of at least one chiral iridium complex. This process yields chiral compounds in a very efficient way and is very advantageous in that the amount of iridium complex can be remarkably reduced.

Processes for producing acetic acid herein generally include contacting methanol and carbon monoxide in the presence of a reaction medium under carbonylation conditions sufficient to form acetic acid, the reaction medium including a carbonylation catalyst selected from rhodium catalysts, iridium catalysts and palladium catalysts; from 1 wt. % to 14 wt. % water; and a plurality of additives, in-situ generated derivatives of the plurality of additives or combinations thereof; the plurality of additives including a first additive including one or more phosphine oxides and a second additive selected from heteropolyacids, metal salts and combinations thereof, the heteropolyacids represented by the formula H.sub.nM.sub.12XO.sub.40, wherein H is hydrogen, M is selected from tungsten and molybdenum, X is selected from phosphorous and silicon and O is oxygen and n is 3 or 4, the metal salts are selected from transition metal salts, lanthanide metal salts and combinations thereof; and recovering acetic acid from the process.

A process for producing acetic acid is disclosed in which the methyl iodide concentration is maintained in the vapor product stream formed in a flashing step. The methyl iodide concentration in the vapor product stream ranges from 24 to less than 36 wt. % methyl iodide, based on the weight of the vapor product stream. In addition, the acetaldehyde concentration is maintained within the range from 0.005 to 1 wt. % in the vapor product stream. The vapor product stream is distilled in a first column to obtain an acetic acid product stream comprising acetic acid and up to 300 wppm hydrogen iodide and/or from 0.1 to 6 wt. % methyl iodide and an overhead stream comprising methyl iodide, water and methyl acetate.

A method of fixating carbon dioxide to a substituted cyclic carbonate includes a reaction of an epoxide and carbon dioxide in the presence of a zirconium-containing metal-organic framework to form the substituted cyclic carbonate. The zirconium-containing metal-organic framework is a UiO-66-based metal-organic framework including an aminomethylbenzoic acid. The zirconium-containing metal-organic framework catalyzes the formation of the substituted cyclic carbonate in a range of 40 to 97 percent yield.

Disclosed are improved catalytic carbonylation methods. In general, the methods are suitable for carbonylating a variety of esters in the presence of carbon monoxide or a source thereof and a catalyst system comprising a transition metal-carbene complex; or a neutral carbene or salt thereof together with a transition metal compound; and a halide source for use as a halide promoter.

Provided are: a catalyst for organic synthesis use, which has a high catalytic activity, can be easily separated by solid/liquid separation from a reaction system, and enables highly efficient synthesis of an organic compound; and a method for producing an organic compound using the catalyst. This catalyst for organic synthesis use includes an anionic exchange resin that has a hydrohalic acid salt of a tertiary amino group as an ion exchange group. This method for producing an organic compound uses, as a catalyst, an anionic exchange resin that has a hydrohalic acid salt of a tertiary amino group as an ion exchange group.

The present disclosure relates to processes of making a compound represented by Formula (I) and methods of use thereof.

The present disclosure relates to processes of making a compound represented by Formula (I) and methods of use thereof.