Disclosed is a covering/lid assembly having a separate first compartment, a second compartment, or both a first and a second compartment, and a button and/or dimple situated on the top side of each compartment. Each compartment will comprise a top side and a bottom side, the bottom side of at least one of the compartments comprising a frangible material. The first or second compartment may comprise a first or a second material. The first material may comprise a red blood cell or blood coagulant or a red blood cell flocculant. Where the first compartment comprises a red blood cell or blood coagulant material, the second compartment will comprise a red blood cell flocculant material. The material from each compartment may be selectively released upon compressing the dimple and/or button of the top side of the respective compartment. A collection and/or biological waste management and disposal system is presented, comprising a covering/lid assembly as described, and a collection container. The covering/lid may include a perimeter having a threaded and/or snap-on assembly suitable for securely attaching the covering/lid assembly to a collection canister. The collection and/or biological waste management and disposal system may include a container comprising a red blood cell flocculant and saline solution. This container may be detachably secured to the canister or provided as a separate accessory to the system.

A system suitable for collecting and transporting urine away from the body of a person or animal may include an assembly having a fluid impermeable casing, a fluid permeable membrane, and a fluid permeable support. A reservoir is defined by the fluid permeable support. The fluid permeable membrane can define a cavity. The casing can define an opening such that the cavity is accessible via the opening. The assembly can also include an outlet in fluidic communication with the reservoir. The assembly can be arranged such that a user's penis can be disposed through the opening with the urethral opening disposed within the cavity and such that a fluid can flow into the body from the urethral opening of the user's penis, collect in the reservoir, and flow out of the outlet.

Harvested adipose tissue is processed in a single-use portable processing container to prepare a centrifuges pellet phase of stromal vascular fraction concentrate, which is selectively removed and disposed in a syringe dispersed in a dispersion medium to prepare an osteoarthritis treatment product.

Disclosed are methods and devices for processing lipoaspirate that include mechanically-processing harvested lipoaspirate in a liposuction filter canister. In some embodiments, the devices are liposuction devices that include a lipoaspirate processing unit for mechanically-processing lipoaspirate. The mechanical processing reduces the average size of adipose tissue pieces in the lipoaspirate without substantially rupturing lipocytes therein.

A morselizer has a first end section with an axially and radially hollow luer fitting, a second end section with an axially and radially hollow luer fitting, a housing juxtaposed therebetween, a channel extending axially between the first end section and the second end section and through the housing providing an axial liquid pathway therein, and at least one blade disposed within the housing. Each end of the morselizer is attachable to a structure with a complimentarily sized luer fitting. In an embodiment, the morselizer facilitates atraumatic resizing of material through axial liquid transfer, by transferring material from a first structure attached to the first end section, thence through the channel, where material is resized by the blade, and through the second end section to a second structure attached to the second end section. The resized material may be suitable for injection, such as through a fine needle.

A portable apparatus useful for collection and processing of human biological material, such as adipose or cancellous bone material, to prepare a concentrated product (e.g., stromal vascular fraction). The apparatus has a container with a containment volume with a tissue retention volume and a filtrate volume separated by a filter and with a pellet well for collecting concentrate product in the form of a pellet phase from centrifuge processing. The pellet well is accessible only from above when the apparatus is in an access orientation. Collected pellet phase material may be removed from the pellet well by direct aspiration, without suspending the material in a suspension liquid within the container. Access ports may be configured for access only from above the container. The apparatus may include a tissue collector disposed in the disuse retention volume to engage and collect collagen or other stringy tissue. A method of processing adipose tissue to concentrate leuko stromal vascular cells includes multi-step processing using a portable container.

Methods of harvesting cancellous bone and bone marrow include extracting loosened cancellous bone and bone marrow—including a liquid component thereof—to a collection container that has a first cup and a suction port to which a suction source is connected. After extraction, the suction source is disconnected and a lid of the collection container is removed and replaced with a lid having a plunger with a press head that is configured to filter the extracted liquid by depressing the plunger toward a bottom of the first cup. The filtered liquid is poured through a suction port into a second cup while depressing the plunger, thereby separating the liquid from a semi-solid mass of cancellous bone that remains. The bone is extracted through a cortical opening in the femur, tibia, or calcaneus, or from an intermedullary canal that is preferably formed by reaming of the tibia using an orthopedic reamer.

A fat conditioning apparatus includes a conditioning vessel enclosing a conditioning chamber and a displacable plug. The conditioning chamber is bounded on one end by the displacable plug and has a variable volume that is a function of the position of the plug within the conditioning vessel. The apparatus has utility in a fat conditioning method, wherein the conditioning chamber contains a harvested fat emulsion. A washing liquid is injected into the conditioning chamber and mixes with the harvested fat emulsion, thereby displacing the plug in an outward expansion direction and expanding the variable volume of the conditioning chamber. The resulting mixture of harvested fat emulsion and washing liquid is stratified in the conditioning chamber into a contaminant-lean fat fraction and a contaminant-rich remainder fraction. The fat fraction, which is substantially free of the remainder fraction, is recovered from the conditioning chamber as a desired product of the method.

Systems and methods for filtering materials from biologic fluids are discussed. Embodiments may be used to filter cerebrospinal fluid (CSF) from a human or animal subject. In an example, CSF is separated into a permeate and retentate using a tangential flow filter. The retentate is filtered again and then returned to the subject with the permeate. During operation of the system, various parameters may be modified, such as flow rate and waste rate.

Disclosed are methods and devices for processing lipoaspirate that include mechanically-processing harvested lipoaspirate in a liposuction filter canister. In some embodiments, the devices are liposuction devices that include a lipoaspirate processing unit for mechanically-processing lipoaspirate. The mechanical processing reduces the average size of adipose tissue pieces in the lipoaspirate without substantially rupturing lipocytes therein.