BUCCAL MICRO-EFFERVESCENT TABLET AND PREPARATION METHOD THEREOF

Abstract

Provided is a buccal micro-effervescent tablet and preparation method thereof. The buccal micro-effervescent tablet comprises a nutrient, a sugar alcohol, an acid source, an alkali source, magnesium stearate, an essence and a sweetening agent, wherein the sugar alcohol is lactose, maltitol, sorbitol, isomaltitol, mannitol, erythritol or any combination thereof; the sweetening agent is sucralose, aspartame, stevioside, fructose, granulated sugar, mogroside or any combination thereof. The micro-effervescent tablet may cause micro effervescence reaction under the action of saliva in mouth.

Claims

1. A buccal micro-effervescent tablet comprising: a nutrient; a sugar alcohol; an acid source; an alkali source; a magnesium stearate; an essence; and a sweetening agent, wherein, the sugar alcohol is lactose, maltitol, sorbitol, isomaltitol, mannitol, erythritol or any combination thereof, the sweetening agent is sucralose, aspartame, stevioside, fructose, granulated sugar, mogroside or any combination thereof, the buccal micro-effervescent tablet comprises in parts by weight: 1-30 parts of the nutrient, 10-80 parts of the sugar alcohol, 10-40 parts of the acid source, 10-40 parts of the alkali source, 0.1-3 parts of the magnesium stearate, 1-5 parts of the essence and 0.1-3 parts of the sweetening agent, a weight ratio of the acid source in the buccal micro-effervescent tablet is not more than 19%, and a weight ratio of the alkali source in the buccal micro-effervescent tablet is not more than 18%.

2. The buccal micro-effervescent tablet according to claim 1, wherein the buccal micro-effervescent tablet comprises in parts by weight: 8-12 parts of the nutrient, 10-80 parts of the sugar alcohol, 10-40 parts of the acid source, 10-40 parts of the alkali source, 0.1-3 parts of the magnesium stearate, 1-5 parts of the essence, and 0.1-3 parts of the sweetening agent.

3. The buccal micro-effervescent tablet according to claim 2, wherein the buccal micro-effervescent tablet comprises in parts by weight: 10-11 parts of the nutrient, 48-63 parts of the sugar alcohol, 11-19 parts of the acid source, 11-18 parts of the alkali source, 0.8-1.5 parts of the magnesium stearate, 1.5-2 parts of the essence, and 0.2-1.2 parts of the sweetening agent.

4. The buccal micro-effervescent tablet according to claim 1, wherein the nutrient is vitamin.

5. The buccal micro-effervescent tablet according to claim 4, wherein the vitamin is vitamin A, vitamins B, vitamin C, vitamin D, vitamin E, vitamin K, or any combination thereof.

6. The buccal micro-effervescent tablet according to claim 1, wherein the sugar alcohol is lactose, maltitol, sorbitol, isomaltitol or any combination thereof.

7. The buccal micro-effervescent tablet according to claim 1, wherein the sweetening agent is sucralose, aspartame, stevioside or any combination thereof.

8. The buccal micro-effervescent tablet according to claim 1, wherein the acid source is citric acid, tartaric acid, fumaric acid, malic acid, or any combination thereof, the alkali source is sodium bicarbonate, sodium carbonate, potassium bicarbonate, potassium carbonate or any combination thereof.

9. The buccal micro-effervescent tablet according to claim 1, wherein the buccal micro-effervescent tablet further comprises silicon dioxide, the weight ratio of the silicon dioxide in the buccal micro-effervescent tablet is 0.1%-1%.

10. The buccal micro-effervescent tablet according to claim 1, wherein the nutrient comprises any one or more selected from the group consisting of blueberry extract, zeaxanthin, lutein, lutein ester, taurine, caffeine, guarana, r-aminobutyric acid, tea theanine, melatonin, milk mineral, grape seed extract, olive fruit extract, collagen powder, elastic collagen, probiotics, ferment, dietary fiber, prebiotics, phosphatidylserine, DHA.

11. A method for preparing the buccal micro-effervescent tablet according to claim 1, comprising: mixing the nutrient, the sugar alcohol, the acid source, the alkali source, the magnesium stearate, the essence, and the sweetening agent to obtain a mixture; and compressing the mixture into a tablet.

Description

SPECIFIC MODES FOR CARRYING OUT THE INVENTION

[0055] The embodiments of the invention are illustrated by way of the following examples. However, a person skilled in the art understands that the following examples are provided for the purpose of describing the invention and shall not be regarded as defining the scope of the invention. The raw materials or auxiliary materials used in the examples are all commercially available.

Example 1

[0056] In parts by weight, the buccal micro-effervescent tablet of the example had the components listed in the prescription as follows.

TABLE-US-00001 lactose 48.8 maltitol 10 vitamin C 10 anhydrous citric acid 14 sodium bicarbonate 14 edible essence 2 sucralose 0.03 aspartame 0.12 stevioside 0.05 magnesium stearate 1

Process:

1. Weighing and Preparing

[0057] All the materials were weighed according to the prescription, and crushed, premixed or sieved selectively according to the properties of the materials.

2. Mixing

[0058] Nutrients, sweetening agents, sugar alcohols, citric acid, sodium bicarbonate, essences, and magnesium stearate were placed in the mixer, and mixed until the mixture was uniform in color and texture.

3. Compressing

[0059] The mixture was compressed into tablets and the size of tablet was 40 mg.

Example 2

[0060] In parts by weight, the buccal micro-effervescent tablet of the example had the components listed in the prescription as follows.

TABLE-US-00002 lactose 16.125 maltitol 35 vitamin C 10.5 anhydrous citric acid 17.5 sodium bicarbonate 16.25 edible essence 1.7 sucralose 0.025 aspartame 0.6 stevioside 0.3 magnesium stearate 1.5 silicon dioxide 0.5

[0061] The Process including mixing and compressing was similar to that in Example 1.

Example 3

[0062] In parts by weight, the buccal micro-effervescent tablet of the example had the components listed in the prescription as follows.

TABLE-US-00003 lactose 9.825 maltitol 42.5 vitamin C 10.5 anhydrous citric acid 17.5 sodium bicarbonate 16.25 edible essence 1.7 sucralose 0.025 aspartame 0.6 stevioside 0.3 magnesium stearate 0.8

[0063] The Process including mixing and compressing was similar to that in Example 1.

Example 4

[0064] In parts by weight, the buccal micro-effervescent tablet of the example had the components listed in the prescription as follows.

TABLE-US-00004 maltitol 62.725 vitamin C 10.5 anhydrous citric acid 11.3 sodium bicarbonate 11.25 edible essence 1.5 sucralose 0.025 aspartame 0.4 stevioside 0.3 magnesium stearate 1.5 silicon dioxide 0.5

[0065] The Process including mixing and compressing was similar to that in Example 1.

Example 5

[0066] In parts by weight, the buccal micro-effervescent tablet of the example had the components listed in the prescription as follows.

TABLE-US-00005 sorbitol 10 lactose 41.625 vitamin C 10 anhydrous citric acid 17.5 sodium bicarbonate 16.25 edible essence 1.7 sucralose 0.025 aspartame 0.6 stevioside 0.3 magnesium stearate 1.5 silicon dioxide 0.5

[0067] The Process including mixing and compressing was similar to that in Example 1.

Example 6

[0068] In parts by weight, the buccal micro-effervescent tablet of the example had the components listed in the prescription as follows.

TABLE-US-00006 sorbitol 30 lactose 25.375 vitamin C 10 anhydrous citric acid 15 sodium bicarbonate 15 essence 1.7 sucralose 0.025 aspartame 0.6 stevioside 0.3 magnesium stearate 1.5 silicon dioxide 0.5

[0069] The Process including mixing and compressing was similar to that in Example 1.

Example 7

[0070] In parts by weight, the buccal micro-effervescent tablet of the example had the components listed in the prescription as follows.

TABLE-US-00007 sorbitol 30 lactose 22.325 vitamin C 10.5 anhydrous citric acid 17.5 sodium bicarbonate 16.25 essence 1.7 sucralose 0.025 aspartame 0.6 stevioside 0.3 magnesium stearate 0.8

[0071] The Process including mixing and compressing was similar to that in Example 1.

Example 8

[0072] In parts by weight, the buccal micro-effervescent tablet of the example had the components listed in the prescription as follows.

TABLE-US-00008 sorbitol 35 lactose 13.625 vitamin C 10.5 anhydrous citric acid 18.75 sodium bicarbonate 17.5 essence 1.7 sucralose 0.025 aspartame 0.6 stevioside 0.3 magnesium stearate 1.5 silicon dioxide 0.5

[0073] The Process including mixing and compressing was similar to that in Example 1.

Example 9

[0074] In parts by weight, the buccal micro-effervescent tablet of the example had the components listed in the prescription as follows.

TABLE-US-00009 lactose 59.375 vitamin C 10.5 anhydrous citric acid 15.25 sodium bicarbonate 11.25 essence 1.5 sucralose 0.025 aspartame 0.8 stevioside 0.3 magnesium stearate 0.5 silicon dioxide 0.5

[0075] The Process including mixing and compressing was similar to that in Example 1.

Example 10

[0076] In parts by weight, the buccal micro-effervescent tablet of the example had the components listed in the prescription as follows.

TABLE-US-00010 isomaltitol 20 lactose 32.275 vitamin C 10.5 anhydrous citric acid 17.5 sodium bicarbonate 16.25 essence 1.7 sucralose 0.025 aspartame 0.6 stevioside 0.35 magnesium stearate 0.8

[0077] The Process including mixing and compressing was similar to that in Example 1.

Example 11

[0078] In parts by weight, the buccal micro-effervescent tablet of the example had the components listed in the prescription as follows.

TABLE-US-00011 isomaltitol 35 lactose 16.075 vitamin C 10.5 anhydrous citric acid 17.5 sodium bicarbonate 16.25 essence 1.7 sucralose 0.025 aspartame 0.6 stevioside 0.35 magnesium stearate 1.5 silicon dioxide 0.5

[0079] The Process including mixing and compressing was similar to that in Example 1.

Example 12

[0080] In parts by weight, the buccal micro-effervescent tablet of the example had the components listed in the prescription as follows.

TABLE-US-00012 isomaltitol 51.35 vitamin C 10.5 anhydrous citric acid 17.5 sodium bicarbonate 16.25 essence 1.7 sucralose 0.025 Aspartame 0.6 stevioside 0.3 magnesium stearate 1.5 silicon dioxide 0.5

[0081] The Process including mixing and compressing was similar to that in Example 1.

Comparative Example 1

[0082] In parts by weight, the buccal micro-effervescent tablet of the comparative example had the components listed in the prescription as follows.

TABLE-US-00013 isomaltitol 34.1 vitamin C 10.5 anhydrous citric acid 27 sodium bicarbonate 24 essence 1.7 sucralose 0.025 aspartame 0.6 stevioside 0.3 magnesium stearate 1.5 silicon dioxide 0.5

[0083] The process included mixing and compressing, and the size of tablet was 4 g.

Comparative Example 2

[0084] In parts by weight, the buccal micro-effervescent tablet of the comparative example had the components listed in the prescription as follows.

TABLE-US-00014 isomaltitol 27.1 vitamin C 10.5 anhydrous citric acid 30 sodium bicarbonate 28 essence 1.7 sucralose 0.025 aspartame 0.6 stevioside 0.3 magnesium stearate 1.5 silicon dioxide 0.5

[0085] The process included mixing and compressing.

Comparative Example 3

[0086] In parts by weight, the buccal micro-effervescent tablet of the comparative example had the components listed in the prescription as follows.

TABLE-US-00015 lactose 16.125 microcrystalline cellulose 35 vitamin C 10.5 anhydrous citric acid 17.5 sodium bicarbonate 16.25 edible essence 1.7 sucralose 0.025 aspartame 0.6 stevioside 0.3 magnesium stearate 1.5 silicon dioxide 0.5

[0087] The process included mixing and compressing.

Comparative Example 4

[0088] In parts by weight, the buccal micro-effervescent tablet of the comparative example had the components listed in the prescription as follows.

TABLE-US-00016 lactose 16.35 maltitol 35 vitamin C 10.5 anhydrous citric acid 17.5 sodium bicarbonate 16.25 edible essence 1.7 aspartame 0.5 stevioside 0.2 magnesium stearate 1.5 silicon dioxide 0.5

[0089] The process included mixing and compressing.

Test Example 1

[0090] On the basis that the sugar alcohol was a combination of maltitol and lactose, the buccal micro-effervescent tablets of vitamin C were prepared by adjusting the ratio of maltitol and lactose. The prescription thereof was shown in the following Table 1. The performance indexes of the buccal micro-effervescent tablet of each group, such as angle of repose, moisture absorption, hardness, friability and the like, were tested, and the test results were shown in Table 2.

TABLE-US-00017 TABLE 1 Prescription of the buccal micro-effervescent table Name of Prescrip- Prescrip- Prescrip- Prescrip- Prescrip- Prescrip- Prescrip- Prescrip- Prescrip- Prescrip- material tion 1 tion 2 tion 3 tion 4 tion 5 tion 6 tion 7 tion 8 tion 9 tion 10 maltitol 40 140 170 204.5 250.9 250.9 260 260 / / lactose 195.2 89.5 39.3 / / / / / 233.5 209.3 vitamin C 40 40 42 42 42 42 40 42 40 42 anhydrous 56 56 70 70 45.2 47 45.9 41.1 56 70 citric acid sodium 56 56 65 65 45 48 42 40 56 65 bicarbonate essence 6.8 6.8 6.8 6.8 6 6 6 6 6.8 6.8 sucralose 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 aspartame 2.4 2.4 2.4 2.4 1.6 1.6 1.6 1.6 2.4 1.6 stevioside 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 magnesium 4 6 3.2 3.2 6 3.2 3.2 6 4 4 stearate silicon / 2 / 2 2 / / 2 / / dioxide Total 400 400 400 400 400 400 400 400 amount of each tablet

TABLE-US-00018 TABLE 2 Test results of performance index of the buccal micro-effervescent tablet Performance Prescrip- Prescrip- Prescrip- Prescrip- Prescrip- Prescrip- Prescrip- Prescrip- Prescrip- Prescrip- Index tion 1 tion 2 tion 3 tion 4 tion 5 tion 6 tion 7 tion 8 tion 9 tion 10 Sense Smooth Smooth Smooth Smooth Smooth Sticking, Sticking, Sticking, Smooth Smooth rough rough rough surface surface surface Angle of 38° 37° 39° 36° 36° 40° 41° 36° 39 39 repose Whether the Success- Success- Success- Success- Success- There was There was There was Success- Success- production fully fully fully fully fully moisture moisture moisture fully fully was completed completed completed completed completed absorption, absorption, absorption, completed completed success- sticking sticking sticking fully occurred occurred occurred completed during during during compressing compressing, compressing for a and the for a long time, production long time, and the could and the production not be production could success- could not be fully not be success- completed success- fully fully completed completed Hardness 5-8 5-8 5-8 5-8 5-8 5-8 5-8 5-8 5-8 5-8 (kg/cm.sup.2) Friability 0.11 0.1 0.11 0.17 0.18 0.24 0.29 0.38 0.23 0.22 (%)

[0091] From the above test results, it could be known that in the present test example, as the amount of maltitol used increased, the moisture absorption of the prescription was enhanced, and accordingly the sticking phenomenon was liable to occur during compressing tablet; and magnesium stearate could improve the sticking phenomenon caused by moisture absorption of the prescription.

Test Example 2

[0092] On the basis that the sugar alcohol was a combination of sorbitol and lactose, the buccal micro-effervescent tablets of vitamin C were prepared by adjusting the ratio of sorbitol and lactose. The prescription thereof was shown in the following Table 3. The performance indexes of the buccal micro-effervescent tablet of each group, such as angle of repose, moisture absorption, hardness, friability and the like, were tested, and the test results were shown in Table 4.

TABLE-US-00019 TABLE 3 Prescription of the buccal micro-effervescent tablet Name of Prescrip- Prescrip- Prescrip- Prescrip- Prescrip- Prescrip- Prescrip- Prescrip- Prescrip- Prescrip- material tion 1 tion 2 tion 3 tion 4 tion 5 tion 6 tion 7 tion 8 tion 9 tion 10 sorbitol 40 80 120 120 140 181.7 219.5 219.5 / / lactose 166.5 126.5 101.5 89.3 54.5 42.6 / / 209.3 196.5 vitamin C 40 40 40 42 42 42 40 42 40 42 anhydrous 70 70 60 70 75 60 64.4 60 70 75 citric acid sodium 65 65 60 65 70 60 62.4 60 65 70 bicarbonate essence 6.8 6.8 6.8 6.8 6.8 6.8 6.8 6.8 6.8 6.8 sucralose 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 aspartame 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.4 2.4 stevioside 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 1.2 magnesium 6 6 6 3.2 6 3.2 3.2 6 3.2 6 stearate silicon 2 2 2 / 2 / / 2 2 / dioxide Total 400 400 400 400 400 400 400 400 400 400 amount of each tablet

TABLE-US-00020 TABLE 4 Test results of performance index of the buccal micro-effervescent tablet Performance Prescrip- Prescrip- Prescrip- Prescrip- Prescrip- Prescrip- Prescrip- Prescrip- Prescrip- Prescrip- Index tion 1 tion 2 tion 3 tion 4 tion 5 tion 6 tion 7 tion 8 tion 9 tion 10 Sense Smooth Smooth Smooth Smooth Smooth Sticking, Sticking, Sticking, Smooth Smooth rough rough rough surface surface surface Angle of 36° 36° 35° 39° 36° 40° 42° 37° 39 38 repose Whether the Success- Success- Success- Success- Success- There There There Success- Success- production fully fully fully fully fully was was was fully fully was completed completed completed completed completed moisture moisture moisture completed completed success- absorption, absorption, absorption, fully sticking severe sticking completed occurred sticking occurred during occurred during compressing during compressing for a long compressing, for a long time, and the and the time, and the production production production could not be could not be could not be success- success- success- fully fully fully completed completed completed Hardness 5-8 5-8 5-8 5-8 5-8 5-8 5-8 5-8 5-8 5-8 (kg/cm.sup.2) Friability 0.15 0.14 0.14 0.12 0.16 0.12 0.16 0.09 0.21 0.19 (%)

[0093] From the above test results, it could be known that in the present test example, as the amount of sorbitol used increased, the moisture absorption of the prescription was enhanced, and accordingly the sticking was liable to occur during compressing tablet; and magnesium stearate could improve the sticking phenomenon caused by the moisture absorption of the prescription.

Test Example 3

[0094] On the basis that the sugar alcohol is a combination of isomaltitol and lactose, the buccal micro-effervescent tablets of vitamin C were prepared by adjusting the ratio of isomaltitol and lactose. The prescription thereof was shown in the following Table 5. The performance indexes of the buccal micro-effervescent tablet of each group, such as angle of repose, moisture absorption, hardness, friability and the like, were tested, and the test results were shown in Table 6.

TABLE-US-00021 TABLE 5 Prescription of the buccal micro-effervescent tablet Name Prescrip- Prescrip- Prescrip- Prescrip- Prescrip- Prescrip- Prescrip- Prescrip- of material tion 1 tion 2 tion 3 tion 4 tion 5 tion 6 tion 7 tion 8 isomaltitol / / 80 140 205.4 230 260 260 lactose 237.5 198.7 129.1 64.3 / / / / vitamin C 42 42 42 42 42 42 42 42 anhydrous 61 75 70 70 70 56.8 45 40.2 citric acid sodium 45 65 65 65 65 52.7 39.3 39.3 bicarbonate essence 6 6.8 6.8 6.8 6.8 6.8 6.8 6.8 sucralose 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 aspartame 3.2 3.2 2.4 2.4 2.4 2.4 2.4 2.4 stevioside 1.2 1.2 1.4 1.4 1.2 1.2 1.2 1.2 magnesium 2 6 3.2 6 6 6 3.2 6 stearate silicon 2 2 / 2 2 2 / 2 dioxide Total 400 400 400 400 400 400 400 400 amount of each tablet Test Smooth Smooth Smooth Smooth Smooth The angle The angle The angle results sense, sense, sense, sense, sense, of repose of repose of repose angle of angle of angle of angle of angle of was 35°, was 40°, was 36°, repose of repose of repose of repose of repose of there was there was there was 36°, and 37°, and 39°, and 36°, and 36°, and moisture moisture moisture successful successful successful successful successful absorption, absorption, absorption, completion completion completion completion completion sticking sticking sticking of of of of of occurred occurred occurred production. production. production. production. production. during during during Hardness: Hardness: Hardness: Hardness: Hardness: compressing compressing, compressing 5-8 kg/cm.sup.2, 5-8 kg/cm.sup.2, 5-8 kg/cm.sup.2, 5-8 kg/cm.sup.2, 5-8 kg/cm.sup.2, for a and the for a Friability: Friability: Friability: Friability: Friability: long time, production long time, 0.23% 0.21% 0.18% 0.15% 0.23% and the could not be and the production successfully production could not be completed. could not be successfully Hardness: successfully completed 5-8 kg/cm.sup.2, completed. . Hardness: Friability: Hardness: 5-8 kg/cm.sup.2, 0.16% 5-8 kg/cm.sup.2, Friability: Friability: 0.15% 0.17%

TABLE-US-00022 TABLE 6 Test results of performance index of the buccal micro-effervescent tablet Performance Prescrip- Prescrip- Prescrip- Prescrip- Prescrip- Prescrip- Prescrip- Prescrip- Index tion 1 tion 2 tion 3 tion 4 tion 5 tion 6 tion 7 tion 8 Sense Smooth Smooth Smooth Smooth Smooth Sticking, Sticking, Sticking, rough rough rough surface surface surface Angle of 36° 37° 39° 36° 36° 35° 40° 36° repose Whether the Successfully Successfully Successfully Successfully Successfully There was There was There was production completed completed completed completed completed moisture moisture moisture was absorption, absorption, absorption, successfully sticking sticking sticking completed occurred occurred occurred during during during compressing compressing, compressing, for a long and the and the time, and the production production production could not be could not be could not be successfully successfully successfully completed completed completed Hardness 5-8 5-8 5-8 5-8 5-8 5-8 5-8 5-8 (kg/cm.sup.2) Friability 0.15 0.21 0.18 0.15 0.23 0.15 0.16 0.17 (%)

[0095] From the above test results, it could be known that in the present test example, as the amount of isomaltitol used increased, the moisture absorption of the prescription was enhanced, and accordingly the sticking phenomenon was liable to occur during compressing tablet; and magnesium stearate could improve the sticking phenomenon caused by the moisture absorption of the prescription.

Test Example 4

[0096] Five sensory indexes including appearance, odour, mouthfeel, being or not being convenient to eat and novelty of the products of Example 1 and Comparative example 1 of the present invention were evaluated by 14 senior sensory assessors, each index had a full score of 5, and the total full score of five sensory indexes was 25. The scoring results were averaged. The scoring results of sensory index were as follows.

TABLE-US-00023 TABLE 7 Scoring results of sensory evaluation of the buccal micro-effervescent tablets of Example 1 Being or not being No. of convenient Total assessor Appearance Odour Mouthfeel to eat Novelty score 1 4 4 4 5 5 22 2 3 4 4 5 5 21 3 4 4 4 4 4 20 4 4 3 3 5 5 20 5 4 3 4 4 4 19 6 3 4 4 5 5 21 7 2 4 4 4 4 18 8 3 4 5 5 5 22 9 4 3 3 5 4 19 10 3 3 4 5 5 20 11 3 4 4 4 4 19 12 2 4 4 5 5 20 13 2 3 3 5 4 17 14 2 3 4 4 5 18 Average 3.07 3.57 3.86 4.64 4.57 19.71 Score

TABLE-US-00024 TABLE 8 Scoring results of sensory evaluation of effervescent tablets of Comparative example 1 Being or not being No. of convenient Total assessor Appearance Odour Mouthfeel to eat Novelty score 1 4 4 4 4 4 20 2 3 4 4 3 4 18 3 4 4 4 3 3 18 4 3 3 3 4 3 16 5 3 2 3 3 3 14 6 3 3 3 3 4 16 7 3 3 4 4 3 17 8 2 4 4 3 3 16 9 4 3 3 4 4 18 10 2 2 3 3 3 13 11 3 3 3 4 3 16 12 2 4 4 3 4 17 13 4 2 4 3 3 16 14 4 3 3 3 4 17 Average 3.14 3.14 3.5 3.36 3.43 16.57 Score

[0097] From the above results, it could be known that the product of Example 1 could be designed to have a cute appearance, had a good aroma, was sour, sweet and palatable when dissolved in mouth, was very convenient to eat, was novel, could be designed to be a snack, and had a high acceptability.

[0098] The product of Comparative Example 1 had a common appearance, was in a common tablet shape, had a good aroma, was sour, sweet and palatable when dissolved in water, and was convenient to eat. The package thereof was designed to be a medicine, and the acceptability thereof was common. In Comparative Example 1, the amount of acid and alkali used was large, the effervescence was violent, and the mouthfeel was not good.

Test Example 5

[0099] The sticking phenomenon of the products of examples 1-12 and comparative examples 1-4 was observed, and the mouthfeel thereof was evaluated and described.

[0100] The results were as follows.

TABLE-US-00025 TABLE 9 Sticking performance and mouthfeel of each effervescent tablet Test items Sticking Phenomenon Mouthfeel Example 1 Not easy to cause sticking Good mouthfeel, pleasant aroma Example 2 Not easy to cause sticking Good mouthfeel, pleasant aroma Example 3 Not easy to cause sticking Good mouthfeel, pleasant aroma Example 4 Not easy to cause sticking Good mouthfeel, pleasant aroma Example 5 Not easy to cause sticking Good mouthfeel, pleasant aroma Example 6 Not easy to cause sticking Good mouthfeel, pleasant aroma Example 7 Not easy to cause sticking Good mouthfeel, pleasant aroma Example 8 Not easy to cause sticking Good mouthfeel, pleasant aroma Example 9 Not easy to cause sticking Good mouthfeel, pleasant aroma Example 10 Not easy to cause sticking Good mouthfeel, pleasant aroma Example 11 Not easy to cause sticking Good mouthfeel, pleasant aroma Example 12 Not easy to cause sticking Good mouthfeel, pleasant aroma Comparative Generating heat causes Good mouthfeel, pleasant Example 1 sticking during aroma compression. Comparative Generating heat causes Good mouthfeel, pleasant Example 2 sticking during aroma compression. Comparative Not easy to cause sticking Rough mouthfeel, surface of Example 3 the tablet being not smooth when buccally taken Comparative Not easy to cause sticking Insufficient fragrance and Example 4 aroma being not obvious

[0101] The foregoing is only a part of the embodiments of the present invention, and it should be noted that, for those skilled in the art, various modifications can be made without departing from the principle of the present invention, and these should also be construed as the scope of the present invention.