Disclosed are new polymeric materials that respond to a mechanical force. The novel polymeric compounds contain an isomer of aziridine, a three-membered N-heterocyclic compound. Also disclosed are methods for preparing the polymeric compounds. Mechanical force-induced cycloaddition of aziridines as mechanophores yields stereospecific products without covalent bond cleavage of aziridines. That is, a mechanical force makes the mechanochemical products stereospecific. The stereospecific products prepared from the isomeric mechanophores by a mechanical force can be widely used in various industrial fields, including new materials.

Provided is a hydrogenated product of a cyclic polymer including a cyclic chain that includes a repeating unit of a ring-opened cycloolefin.

Methods of preparing oligomers including heating a mixture of an amount of a functionalized cycloalkene, an amount of a chain transfer agent, a phosphite ester, and a catalyst, a degree of polymerization of the oligomers controllable by a molar ratio of the amount of the functionalized cycloalkene to the amount of the chain transfer agent, are provided herein. Methods of preparing polymers including heating the oligomers and a second amount of the functionalized cycloalkene, a phosphite ester, and a catalyst are further provided. Compositions of oligomers and functionalized cycloalkenes are further provided.

Materials (e.g., particles, hydrogels) that provide extended release of one or more therapeutic agents are useful platforms for drug delivery. In part, the present invention relates to new triblock (ABC) bottlebrush copolymers which can be used in the formulation of particles and hydrogels for the extended release of therapeutic agents. In certain embodiments, the triblock bottlebrush copolymers, particles, and hydrogels described herein are thermally-responsive and gel at physiological temperature (e.g., upon administration to a subject), providing injectable and/or implantable gels which can be used for extended release drug delivery. The present invention also provides methods for extended release drug delivery, and methods of treating and/or preventing a disease or conditions in a subject, using the inventive copolymers, particles, and hydrogels. In addition, the present invention provides methods of preparing the triblock bottlebrush copolymers described herein.

Embodiments in accordance with the present invention encompass compositions encompassing a latent organo-ruthenium compound, a photosensitizer and one or more monomers which undergo ring open metathesis polymerization (ROMP) when said composition is exposed to suitable actinic radiation to form a substantially transparent film or a three dimensional object. Surprisingly, the compositions are very stable at ambient conditions to temperatures up to 80° C. for several weeks and undergo mass polymerization only when subjected to actinic radiation under inert atmosphere such as for example a blanket of nitrogen. Accordingly, compositions of this invention are useful in various opto-electronic applications, including as 3D printing materials, coatings, encapsulants, fillers, leveling agents, among others.

A tetraanionic OCO pincer ligand metal-oxo-alkylidene complex is prepared from a trianionic pincer ligand supported metal-alkylidyne. The metal can be tungsten or other group 5-7 transition metal. The tetraanionic pincer ligand metal-oxo-alkylidene complex, a trianionic OCO pincer ligand metal complex, or a trianionic ONO pincer ligand metal complex can be used to polymerize cycloalkenes. The poly(cycloalkene)s are predominantly cis-alkene macrocyclics.

A cyclic olefin-based copolymer resin composition includes a cyclic olefin-based copolymer (M); and a maleimide compound (L), in which the cyclic olefin-based copolymer (M) includes a cyclic olefin-based copolymer (m) including a repeating unit represented by a specific general formula, the maleimide compound (L) has a solubility parameter (SP value) obtained by Fedors method of 19J.sup.1/2/cm.sup.3/2 or more and 26J.sup.1/2/cm.sup.3/2 or less and includes a maleimide compound (1), which is a bismaleimide compound having at least two maleimide groups in a molecule, and when a total of the cyclic olefin-based copolymer (M) and the maleimide compound (L) is 100 parts by mass, a content of the maleimide compound (L) is 1 part by mass or more and 50 parts by mass or less.

In an aspect, the invention provides therapeutic agents comprising brush polymers that address challenges associated with conventional administration of free therapeutic peptides. In an embodiment, for example, the invention provides brush polymers incorporating one or more therapeutic peptides as side chain moieties. Therapeutic agents of the invention comprising brush polymers include high-density brush polymers including cross-linked brush polymers and brush block copolymers. In an embodiment, brush polymers of the invention exhibit proteolysis-resistant characteristics and maintain their biological function during formulation and administration. The invention also includes methods of making and using therapeutic agents comprising brush polymers.

A phase difference film formed of a resin containing a polymer having crystallizability, wherein: a coefficient of variation CV(Re) of an in-plane retardation of the phase difference film at a measurement wavelength of 590 nm is 1.0% or less.

Provided is a polymerizable composition comprising a cycloolefin-based monomer having a specific structure, a silane coupling agent having at least one hydrocarbon group having a norbornene structure, and a metathesis polymerization catalyst.