C07K14/1841

Method of inducing a cross-reactive HIV-1 immune response by administering a composition comprising the GBV-C E2 protein

GB virus C (GBV-C or hepatitis G virus) is a flavivirus that frequently leads to chronic viremia in humans. The invention provides compositions and methods involving an anti-GBV-C antibody or other GBV-C binding agent, or a GBV-C antigen, for inhibiting and treating HIV infections.