An antimicrobial treatment system comprises a wearable photoactivation device. The wearable photoactivation device includes a body configured to be positioned on a head of a subject over one or more eyes of the subject. The body includes one or more windows or openings that allow the one or more eyes to see through the body. The body includes one or more photoactivating light sources coupled to the body and configured to direct photoactivating light to the one or more eyes according to illumination parameters. The illumination parameters determine a dose of the photoactivating light that activates, according to photochemical kinetic reactions, a photosensitizer applied to the one or more eyes and generates reactive oxygen species that provide an antimicrobial effect in the one or more eyes, without substantially inducing cross-linking activity that produces biomechanical changes in the one or more eyes.

An ophthalmological device (10) for the treatment of corneal diseases such as keratocanus and glaucoma, comprises a molding head (12), a suction body (14) and a UV lamp (15). The molding head (12) has a hollow cylindrical configuration and includes a rigid molding lens (18) for shaping the cornea of an eye (11) of a patient. The lens is curved and defines a plurality of apertures therein. The suction body (14) has a hollow cylindrical configuration. The lamp (15) is fitted to the suction body. Molding head (12) and suction body (14) together define a chamber (32) from which air is evacuated so as to induce a partial vacuum within the chamber (32) for attracting the cornea onto the lens (18). A photo-sensitizer is applied to the eye and while the cornea is held against the mold, it is irradiated with UV light by lamp (15) so as to cross-link collagen fibers in the cornea.

Systems and methods for monitoring properties of the cornea and controlling the crosslinking treatment. The thickness of the cornea during crosslinking may be measured by using ultrasonic reflections to determine an anterior distance (D.sub.1′) between a reference location (37) on a device resting on the eye and an anterior surface (66) of the cornea and to determine a posterior distance (D.sub.3′) between a posterior surface (63) of the cornea and an element of the eye such as an anterior surface (72) of the lens of the eye. These distances are subtracted from a reference distance (D.sub.0) between the reference location and the element of the eye. The reference distance (D.sub.0) may be determined using ultrasonic reflections to determine the corresponding anterior and posterior distances and the thickness (D.sub.2) of the cornea prior to crosslinking. The speed of sound in the cornea during crosslinking may be derived using the thickness (D2′) and time of flight of ultrasound through the cornea. The position of the cornea relative to a reference location may be determined. In still other embodiments, location of a surface of demarcation (86) within the cornea formed as a result of crosslinking may be determined. Still other embodiments provide for determination of one or more resonant frequencies of the cornea, and for measurement of responses of the cornea to applied forces, such as displacement and rebound velocity. The properties of the cornea may be used as proxies for the extent of crosslinking, and a light source (48, 348) used to induce crosslinking may be controlled in response to such proxies.

A method of preventing capsular opacification and fibrosis utilizing an accommodative intraocular lens implant, which includes the steps of removing a cortex and nucleus of a natural lens containing a cataract from a lens capsule of an eye of a patient; applying a photosensitizer inside the lens capsule so that the photosensitizer permeates a portion of the lens capsule, the photosensitizer facilitating cross-linking of the tissue in the portion of the lens capsule; irradiating the portion of the lens capsule so as to activate cross-linkers in the tissue in the portion of the lens capsule, thereby damaging the remaining lens epithelial cells in the lens capsule with the irradiated light so as to prevent capsular opacification and fibrosis; and injecting a transparent polymer into the lens capsule of the eye in order to form an accommodative intraocular lens for replacing the cortex and nucleus of the natural lens.

An ophthalmic phototherapy device and associated phototherapy treatment method tor promoting healing of damaged or diseased eye tissue. The ophthalmic phototherapy device includes a light emitting mechanism for transmitting light of at least one preselected wavelength to the eye tissue. The ophthalmic phototherapy method includes directing light of at least one wavelength for a selected period of time to a portion of damaged or diseased eye tissue, whereby the light transmitted to the damaged or diseased eye tissue stimulates cellular activity in the eye tissue to promote healing.

An optical system for eye surgery, comprising at least a surgical microscope, an illumination unit for emitting illumination light, and a control unit.

The surgical microscope is configured to output an observation mode signal indicating the employed observation mode and a mode-of-operation signal indicating the employed mode of operation, and the control unit is configured to receive the observation mode signal and the mode-of-operation signal from the surgical microscope and to output a change signal which prompts a change in the amount of light received by the at least one digital image sensor. The change signal is output only if the received observation mode signal and the received mode-of-operation signal indicate a predetermined combination of observation mode and mode of operation.

Delivery systems and methods for delivering riboflavin (R/F) and UVA irradiation to the sclera are disclosed. The R/F is delivered and then activated with UVA irradiation through the use of LEDs or optical fibers, thereby causing cross-linking of the collagen tissue. Delivery systems include implantable structures which provide surfaces that conform to the sclera. The delivery systems include various types of structures for delivery of R/F onto the sclera surface. Additionally, the delivery systems include UVA sources which provide irradiation of R/F in sclera collagen tissue.

This apparatus treats the lens capsule so as to increase accommodation of the eye. The treatment of the lens capsule may comprise treating a portion of the lens capsule so as to stiffen the treated portion and improve accommodation of the eye. The intermediate portion of the lens capsule may be located between an optically used central portion of the lens capsule and a peripheral portion of the lens capsule connected to zonules of the eye. The stiffened intermediate portion of the lens capsule can improve coupling of the peripheral portion of the lens capsule to the central portion of the lens capsule, such that an amount of accommodation of the optically used central portion of the lens is increased. As the force of the lens capsule to a lens disposed within the lens capsule is increased, the lens may comprise the natural lens of the eye or an artificial lens such as an accommodative IOL. The treatment of the eye to stiffen the intermediate portion may comprise application of one or more of an energy or a substance to the intermediate portion.

The underlying invention is directed to a method for changing the human perceptual color appearance of the iris of a human's or animal's eye by selectively decreasing the density of pigments of the anterior stroma layer of the iris. The method comprises generating, by a generator module, a plurality of predefined energy quantities; and applying, by the generator module, one or more of the predefined energy quantities to the anterior stroma layer, wherein each of the predefined energy quantities is generated and applied, such that the energy quantities ablate, at least in part, melanocytes of the stroma whilst leaving non-melanocyte tissue of at least the stroma essentially undamaged, and wherein the predefined energy quantities generated and applied to the anterior stroma layer in the form of pressure waves and/or pulses generated within a fluid medium that is in fluidical communication with the anterior stroma layer.

Systems, methods, and devices used to treat eyelids, meibomian glands, ducts, and surrounding tissue are described herein. In some embodiments, an eye treatment device is disclosed, which includes a scleral shield positionable proximate an inner surface of an eyelid, the scleral shield being made of, or coated with, an energy-absorbing material activated by a light energy, and an energy transducer positionable outside of the eyelid, the energy transducer configured to provide light energy at one or more wavelengths, including a first wavelength selected to heat the energy-absorbing material.