The neural health or state of a subject is assessed. A recording is obtained of a compound action potential arising in neural tissue of the subject. The recording is processed to determine whether a profile of the recorded compound action potential is anomalous, such as by exhibiting doublets, peak broadening or deformation, or other anomaly. An indication is output regarding the neural state of the subject based on determined anomalies in the recorded compound action potential.

Disclosed herein are systems comprising sensor devices that may be affixed to a patient and used to perform clinical measurements such as measurements for calculating a BASMI score. A first sensor device is configured to be successively attached to each of a wrist carrier, an ankle carrier, and a headset carrier. The carriers are attached to, or positioned next to, the relevant portion of the patient's body in order to perform particular measurements relating to generating a BASMI score. As the patient performs the routine of motions associated with a particular BASMI measurement, the sensor device records the measurements and communicates the measurements to a user computing device. A second sensor device is configured to be applied to the patient's torso and an additional measurement of patient flexibility taken and communicated to the user computing device. The user computing device generates a BASMI score from the recorded measurements.

Device (1) for electrotherapy and/or electrophysiology comprising at least one lead (2) having an elongated lead body extending along a longitudinal direction (X-X) and comprising a proximal end (3) and a distal end (4); and at least one paddle (5) having a paddle body comprising two opposite major surfaces (6, 7) defining a paddle thickness (33) there between; wherein said paddle (5) comprising at least one paddle electrode (8) having an exposed surface (9) designed to come into electrical contact with a living anatomy (10) inside a patient's body (11); said paddle (5) is suitable to modify the transverse encumber (12) thereof, so that to assume at least one transport configuration and at least one operative configuration, wherein the transverse encumber (12) of the paddle (5) when in said at least one transport configuration is less than the transverse encumber (12) of the same paddle (5) when in said at least one operative configuration; wherein said lead (2) comprising a connection portion (13) near the distal end (4) thereof; said connection portion (13) of the lead (2) comprises at least one arched electrically conductive surface (14); and said paddle (5) comprises at least one counter-connection portion (15) comprising at least one arched electrically conductive counter-surface (16) in direct contact with said at least one conductive surface (14) of the connection portion (13) of the lead (2), so that said at least one counter-connection portion (15) of the paddle (5) has a transversally arched shape defining a first concavity (R1) facing towards said connection portion (13) of the lead (2); said at least one conductive counter-surface (16) of the paddle (5) is in electric communication with said paddle electrode (8) through at least one conductive track (17) extending within the body of paddle (5) in such way that said proximal end (3) of the lead (2) is in electrical communication with said exposed surface (9) of the at least one paddle electrode (8).

Example systems and techniques for denervation, for example, renal denervation. In some examples, a processor determines one or more tissue characteristics of tissue proximate a target nerve and a blood vessel. The processor may generate, based on the one or more tissue characteristics, an estimated volume of influence of denervation therapy delivered by a therapy delivery device disposed within the blood vessel. The processor may generate a graphical user interface including a graphical representation of the tissue proximate the target nerve and the blood vessel and a graphical representation of the estimated volume of influence.

Systems and methods for positioning implanted devices in a patient are disclosed. A method in accordance with a particular embodiment includes, for each of a plurality of patients, receiving a target location from which to deliver a modulation signal to the patient's spinal cord. The method further includes implanting a signal delivery device within a vertebral foramen of each patient, and positioning an electrical contact carried by the signal delivery device to be within ±5 mm. of the target location, without the use of fluoroscopy. The method can still further include, for each of the plurality of patients, activating the electrical contact to modulate neural activity at the spinal cord. In further particular embodiments, RF signals, ultrasound, magnetic fields, and/or other techniques are used to locate the signal delivery device.

An echo planar imaging technique in which a quadruple echo gradient and spin echo echo-planar imaging pulse sequence is utilized. The pulse train includes generation of two echo trains between an excitation pulse (90) and a refocusing pulse (180) to achieve two gradient echo images (also called T2*-weighted images); with one echo train directly after the 180 pulse, leading to asymmetric spin echo images (T2′-weighted images); and a last echo train afterward that generates spin echo images (T2-weighted). The technique has a number of advantages over existing techniques with regard to voxel size, mapping relative oxygen extraction, determining permeability, determining relative cerebral blood volume, vessel parameters (diameter, density, size, arterial/venous, etc.), stroke imaging, imaging perfusion, fMRI imaging, and additional benefits.

The invention provides a closed-loop spinal cord electrical stimulation system, including a spinal epidural electrical stimulation electrode, a low limb electrical stimulation electrode, a closed-loop electrical stimulator and a controller. The spinal epidural electrical stimulation electrode, the low limb electrical stimulation electrode and the controller are electrically connected to the closed-loop electrical stimulator respectively. The spinal epidural electrical stimulation electrode is used for applying a first electrical stimulation to the spinal epidural site, and the low limb electrical stimulation electrode is used for applying a second electrical stimulation to a low limb. The voltage of the first electric stimulation is 400-600 mV, the voltage of the second electric stimulation is 1 V-1.5 V, and the stimulation frequency of the both is 10-20 Hz. The stimulation system can send electrophysiological signals similar to sensorimotor neural circuitry to the subject with spinal cord injury, and can activate and remodel the neural circuit.

Aspects of the disclosure relate to methods of conducting an intraoperative procedure including providing an electrode assembly having a pledget substrate having a surface that is hydrophilic, at least one electrode supported by and positioned within the pledget substrate, and a lead wire assembly interconnected to the at least one electrode. Methods can further include creating an incision to access bioelectric tissue of a patient and applying the pledget substrate to the tissue, such as a nerve, for example. The pledget substrate conforms and fixates to the tissue to secure the electrode assembly in position. The electrode is then activated to record bioelectric responses of or stimulate the tissue. In some embodiments, the pledget substrate includes two bodies, each including at least one electrode, the two bodies being selectively separable so that the bodies can be repositioned with respect to one another.

Epidural electrical stimulation (EES) systems and techniques for accessing and locating targeted spinal cord segments are disclosed. In some examples, a method includes providing a first set of electrodes of an EES system at a first set of locations on the dura mater of a spine of a mammal, the first set of locations on the dura mater corresponding to a first muscle group of the mammal; providing a second set of electrodes of the epidural electrical stimulation system at a second set of locations on the dura mater of the spine of the mammal, the second set of locations on the dura mater corresponding to a second muscle group of the mammal; and stimulating the first and second sets of locations on the dura mater by electrically energizing the first and second sets of electrodes, respectively, thereby activating the first and second muscle groups in a coordinated manner.

Automated assessment of neural response recordings involves storing a set of basis functions comprising at least one compound action potential basis function and at least one artefact basis function. Neural recordings of electrical activity in neural tissue are obtained by application of stimuli, using a single configuration of stimulation and recording. Each neural recording is decomposed by determining at least one parameter which estimates at least one of a compound action potential and an artefact. The at least one parameter is/are determined for each respective one of the plurality of neural recordings, to yield a plurality of values. A spread of the plurality of values is determined. An indication that the neural response recordings are of higher quality is output if the spread is small. An indication that the neural response recordings are of lower quality is output if the spread is large.