Various embodiments disclosed relate to drug-coated balloon catheters for treating strictures in body lumens and methods of using the same. A drug-coated balloon catheter for delivering a therapeutic agent to a target site of a body lumen stricture includes an elongated balloon having a main diameter. The balloon catheter includes a coating layer overlying an exterior surface of the balloon. The coating layer includes one or more water-soluble additives and an initial drug load of a therapeutic agent.

Various embodiments of the present invention provide a conduit device including an attaching device configured for defining a helical pathway through a tissue wall and complementary ring in cooperation for securing the device within an aperture defined in the tissue wall. Some embodiments of the present invention further provide a system for implanting a conduit device in a tissue wall. More specifically, some embodiments provide a system including a coring device for defining an aperture in a tissue by removing and retaining a tissue core and securely implanting a conduit device therein so as to provide fluid communication between a first and second surface of the tissue wall via the conduit device.

Provided herein are solid pharmaceutical compositions comprising erdafitinib, processes for making such formulations, and drug delivery systems comprising such formulations, including systems for intravesical administration.

Described is a catheter arrangement in which a sealed container of wetting agent is provided in a housing cap. The sealed container is pierced with a piercing member such that the wetting agent is directed towards the catheter. The wetting agent may bypass a handling surface of the catheter whilst being directed to the catheter tube.

In one embodiment, the present application discloses, in part, a balloon catheter assembly comprising: a) a balloon catheter comprising a proximal end, a distal end; and b) a connecting line comprising a proximal end and a distal end, wherein the proximal end comprises a first terminal magnetic connector for forming a water tight connection with the magnetic click connector on the port panel.

Embodiments disclosed herein are directed to a dynamic pressure response drainage system including control logic configured to enable measuring of residual fluid disposed within the drainage lumen. The residual fluid volume is measured by detecting the magnitude of the dynamic pressure response in the system containing the residual fluid when a sudden displacement (e.g. increase or decrease) of air volume occurs inside the system. The pressure burst magnitude is related to the pressure needed to move the mass of fluid, thus the fluid volume can be calculated from measurements of the burst pressure. The magnitude of the measured air pressure exhibits a dynamic pressure response corresponding to the mass of fluid in the tube. Either positive or negative pressure bursts can be used to produce and measure the corresponding positive or negative dynamic response spike pressure.

A method for removing fluid from a patient is provided, the method including: deploying a ureteral stent or ureteral catheter into a ureter of a patient to maintain patency of fluid flow between a kidney and a bladder of the patient; deploying a bladder catheter into the bladder of the patient, wherein the bladder catheter comprises a distal end configured to be positioned in a patient's bladder, a drainage lumen portion having a proximal end, and a sidewall extending therebetween; and applying negative pressure to the proximal end of the bladder catheter to induce negative pressure in a portion of the urinary tract of the patient to remove fluid from the patient. Systems and kits related thereto also are provided.

In one aspect, the present invention provides implantable or insertable urological medical devices, which are adapted to deliver one or more urologically beneficial agents in pharmaceutically effective amounts. In one aspect, the invention provides medical devices in which urologically beneficial agents are delivered using a porous membrane.

Disclosed is a bladder drainage apparatus comprising a tube including a hollow interior extending through the tube, a flexible anchor, which behaves spring-like, connected to or at one end of the tube, and a magnetic member connected to or at the other end of the tube. The tube is moveable when the magnetic member is engaged by an external magnetic force, creating magnetic traction, and moving the tube, e.g., outward (from its original position, where the sphincter is typically closed), such that it holds open a sphincter, allowing urine to drain from the bladder, to the urethra, to outside of the body. When the external magnetic force is released, the magnetic engagement is terminated, and the force of the flexible anchor pulls the tube back to its original position, whereby the sphincter is again closed, and accordingly urine flow is stopped or otherwise limited.

A catheter insertion device which employs back-and-forth longitudinal axial movement to advance the catheter by the cooperative interface of an incline ramp and a decline ramp with a split gripping mechanism is described.